| 钟建秋,王欣璐,尹吉林,张金赫.聚酰胺-胺树状聚合物靶向修饰及放射性核素标记研究进展[J].中国医学影像技术,2016,32(12):1947~1950 |
| 聚酰胺-胺树状聚合物靶向修饰及放射性核素标记研究进展 |
| Progresses of targeted modification and radionuclide label of Polyamidoamine dendrimers |
| 投稿时间：2016-04-10 修订日期：2016-09-01 |
| DOI：10.13929/j.1003-3289.2016.12.038 |
| 中文关键词: 聚酰胺-胺 纳米微粒 靶向 同位素标记 |
| 英文关键词:Polyamidomine Nanoparticles Targeting Isotope labeling |
| 基金项目:广东省自然科学基金（2016A030313612）。 |
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| 中文摘要: |
| 纳米分子在体内具有药物载体的特性，与生物靶向分子结合，可实现药物的靶向传递；与放射性核素的结合，可实现在体内靶向分布与靶向聚集的可视化，从而达到对特定病变的显像或治疗作用。本文对近年来新型树状纳米分子聚乙酰胺-胺（PAMAM）的靶向分子修饰及核素标记的研究进展进行综述。 |
| 英文摘要: |
| Nanomolecules have the property of drug delivery in vivo, which combined with the biological targeting molecules can achieve targeted drugs delivery, and combined with radionuclides can make the targeting distribution and aggregation visualized. Therefore, nanomolecules can be used in the detection and treatment for a particular lesion. The recent progresses of a new type of dendritic nanomolecule polyamidoamine (PAMAM) for targeted molecular modification and radiolabeled studies were reviewed in this article. |
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