| 周金发,朱建国,李海歌,张发明,刘斐,周良,翟华俊,曹鹏.MRI定量参数评估肠道克罗恩病病变活动性[J].中国医学影像技术,2016,32(12):1895~1899 |
| MRI定量参数评估肠道克罗恩病病变活动性 |
| MRI quantitative parameters in assessment of activity of Crohn's disease |
| 投稿时间：2016-06-20 修订日期：2016-09-21 |
| DOI：10.13929/j.1003-3289.2016.12.026 |
| 中文关键词: 克罗恩病 Harvey-Bradshow指数 C反应蛋白 扩散磁共振成像 对比剂 表观扩散系数 容积转运常数 |
| 英文关键词:Crohn's disease Harvey-Bradshow index C-reactive protein Diffusion magnetic resonance imaging Contrast media Apparent diffusion coefficient Volume transfer constant |
| 基金项目:2014年江苏省级条件建设与民生科技专项资金（第三批；BL2014097）、南京医科大学科技发展基金重点项目（2015NJMUID035）。 |
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| 中文摘要: |
| 目的 探讨MRI定量参数ADC与容积转运常数（Ktrans）评估肠道克罗恩病（CD）病变活动性的应用价值。方法 收集50例回盲部单发病灶的CD患者，依次行常规MR、DWI和动态增强MRI（DCE-MRI）扫描，测量ADC和Ktrans值，同时评估患者Harvey-Bradshow指数（HBI）和血清C反应蛋白（CRP）浓度。根据HBI将50例患者分为重度活动组、轻中度活动组及静止组，比较3组间Ktrans、ADC值的差异；对Ktrans、ADC值与对应的HBI、CRP行相关性分析。结果 50例CD患者中，静止组16例、轻中度活动组21例、重度活动组13例。3组Ktrans、ADC值的差异均有统计学意义（P均<0.05），组间两两比较差异均有统计学意义（P均<0.05）。病变肠壁Ktrans值与HBI呈正相关（r=0.635，P<0.001），与CRP呈正相关（r=0.764，P<0.001）；ADC值与HBI呈负相关（r=-0.614，P<0.001），与CRP呈负相关（r=-0.490，P<0.001）。病变肠壁HBI与CRP呈正相关（r=0.755，P<0.001），Ktrans与ADC值呈负相关（r=-0.348，P=0.013）。结论 MRI定量参数Ktrans和ADC可反映CD活动状态，且Ktrans的稳定性和敏感性优于ADC。 |
| 英文摘要: |
| Objective To explore the value of MRI quantitative parameters including ADC and volume transfer constant (Ktrans) in assessment of the activity of Crohn's disease. Methods Fifty patients with CD were recruited, and all subjects underwent bowel examination with conventional MR, DWI and dynamic contrast-enhanced (DCE) scan. The quantitative parameters (ADC, Ktrans) and clinical data (Harvey-Bradshow index, C-reactive protein) were collected. According to HBI, all CD patients were divided into three groups such as severe group, mild-moderate group and static group. The differences of Ktrans and ADC among the three groups were compared. The correlation between quantitative parameters of MRI (ADC, Ktrans) and clinical data (HBI, CRP) were evaluated. Results In fifty patients with CD, there were 16 cases of static group, 21 cases of mild-moderate active group and 13 cases of severe group. The differences of Ktrans and ADC values among the three groups were statistically significant (P<0.05), and there were significant differences between any two groups (all P<0.05). There was positive correlations between Ktrans and HBI (r=0.635, P<0.001) and CRP (r=0.764, P<0.001). ADC value was negatively correlated with HBI (r=-0.614, P<0.001) and CRP (r=-0.490, P<0.001). There was a positive correlation between HBI and CRP (r=0.755, P<0.001). Ktrans was negatively correlated with ADC (r=-0.348, P=0.013). Conclusion Quantitative parameters of MRI (Ktrans and ADC) are contributed to assess the severity of CD, and Ktrans is more sensitive and stability. |
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