| 李子朋,程文文,王海宝,余永强.急性酒精暴露脑功能改变的静息态fMRI[J].中国医学影像技术,2016,32(12):1848~1851 |
| 急性酒精暴露脑功能改变的静息态fMRI |
| Resting-state fMRI of brain functional changes in acute alcohol exposure |
| 投稿时间：2016-06-13 修订日期：2016-09-01 |
| DOI：10.13929/j.1003-3289.2016.12.014 |
| 中文关键词: 酒精暴露 磁共振成像 分数低频振幅 脑功能 |
| 英文关键词:Alcohol exposure Magnetic resonance imaging Fractional amplitude of low frequency fluctuations Brain function |
| 基金项目:国家自然科学基金（8171326、81571308）、安徽省高校自然科学研究基金（KJ2013ZD08）、高等学校博士学科点专项科研基金（20123420110001）。 |
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| 中文摘要: |
| 目的 通过静息态fMRI检测健康成年人饮酒前后脑分数低频振幅（fALFF）的改变，探讨急性酒精暴露后脑功能变化特点。方法 共纳入健康成年男性19名，通过3.0T MR仪器采集饮酒前后脑静息态功能数据，计算标准化fALFF值，并进行配对t检验比较其差异。结果 酒精暴露下fALFF值明显降低的脑区包括：右侧角回/枕中回、右侧额上回眶部、右侧额上回背内侧（P均<0.001）；fALFF值增加的脑区包括：右侧颞上回后部、右侧中央岛盖，右侧颞上回颞极部（P均<0.001）。结论 健康成年人饮酒后静息态脑网络发生广泛性改变，并存在功能增强和减弱脑区。 |
| 英文摘要: |
| Objective To explore the changes of brain function in acute alcohol exposure healthy individuals, according to the difference of the fractional amplitude of low-frequency fluctuation (fALFF) of brain before and after drinking alcohol measured by resting-state fMRI. Methods Nineteen healthy male volunteers were examined by rest-state fMRI scans on a 3.0T MRI scanner before and after drinking alcohol. The standardized fALFF value were calculated, and the statistical differences were analyzed with paired t-test. Results In contrast to pre-alcohol, the functional decreased brain regions of post-alcohol were the right angular gyrus/the right middle occipital gyrus, the orbital part of the right superior frontal gyrus and the dorsomedial part of the right superior frontal gyrus (all P<0.001), while functional increased brain regions were the right superior temporal gyrus, right central operculum area and right superior temporal pole (all P<0.001). Conclusion The extensive resting-state network changes after drinking alcohol in healthy adults, and resting-state fMRI can show the functional increased and decreased brain areas. |
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