| 杨静,郑容.131I治疗分化型甲状腺癌肺转移患者的疗效及其影响因素[J].中国医学影像技术,2016,32(10):1624~1627 |
| 131I治疗分化型甲状腺癌肺转移患者的疗效及其影响因素 |
| Curative effect and influencing factors of 131I in treatment of differentiated thyroid cancer patients with pulmonary metastases |
| 投稿时间：2016-04-18 修订日期：2016-06-06 |
| DOI：10.13929/j.1003-3289.2016.10.038 |
| 中文关键词: 甲状腺肿瘤 肿瘤转移 肺 碘放射性同位素 |
| 英文关键词:Thyroid neoplasms Neoplasms metastasis Lung Iodine radioisotopes |
| 基金项目: |
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| 中文摘要: |
| 131I治疗分化型甲状腺癌（DTC）肺转移的疗效确切，可有效提高DTC肺转移患者的治愈率和有效率，显著改善DTC肺转移患者的远期疗效，提高患者生存率。影响131I治疗DTC肺转移疗效的因素主要包括治疗剂量和次数、患者年龄、131I的摄取能力及有效半衰期、有无其他远处转移、肺转移灶大小、病理类型、血促甲状腺激素水平、首次治疗前血清甲状腺球蛋白水平。131I治疗DTC肺转移患者的安全性较高，主要不良反应有肺功能损伤、胃肠道反应、颈部肿胀疼痛和唾液腺功能异常。本文对131I治疗DTC肺转移患者的疗效及其影响因素进行综述。 |
| 英文摘要: |
| 131I therapy has proven effective in treatment of differentiated thyroid cancer (DTC) patients with pulmonary metastases.131I therapy can enhance the cure rate, efficiency, long-term efficacy and survival rate of DTC patients with lung metastases. Factors that affect the efficacy of 131I therapy on DTC patients with lung metastases include dose and frequency of treatment, patients' age, 131I uptake capacity and effective half-life, whether combined with other distant metastases, the size of pulmonary metastases, histological type, serum thyroid stimulating hormone level and thyroglobulin level for the first time before treatment. 131I therapy has proven to be of high security to DTC patients with lung metastases. The main adverse reactions are lung function damage, gastrointestinal irritation, neck swell and ache, salivary glands dysfunction. Curative effect and influencing factors of 131I in treatment of DTC patients with pulmonary metastases were reviewed in this paper. |
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