| 魏小二,李跃华,赵晖,傅敏,李文彬.高压氧治疗后MRI定量测定预测脑创伤预后[J].中国医学影像技术,2016,32(6):829~834 |
| 高压氧治疗后MRI定量测定预测脑创伤预后 |
| Quantitative MRI after hyperbaric oxygen in prediction of neurofunction prognosis of traumatic brain injury |
| 投稿时间：2015-09-09 修订日期：2015-11-03 |
| DOI：10.13929/j.1003-3289.2016.06.004 |
| 中文关键词: 高压氧 磁共振成像 预测 脑损伤 |
| 英文关键词:Hyperbaric oxygenation Magnetic resonance imaging Forecasting Brain injury |
| 基金项目:国家自然科学基金(81301213、81271540、81000609)。 |
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| 中文摘要: |
| 目的 探讨外伤后早期对血脑屏障通透性和细胞毒性脑水肿的定量检测在预测高压氧治疗预后中的价值。方法 将21只实验兔随机分为2组,即外伤＋高压氧组(n=15),假手术＋高压氧组(n=6)。两组实验兔接受7天共10次的高压氧治疗。在外伤后的3 h,1、3、7、30天对上述实验兔分别进行MR扫描。此外,在外伤前、外伤后1天和30天对所有实验兔进行神经功能(VCS)评分。结果 TBI+HBO组的VCS评分在外伤后1天和30天均低于外伤前(P=0.001),外伤后30天的VCS评分大于外伤后1天(P=0.001)。在局部病灶区,外伤后1天和3天的Ktrans值与30天的VCS评分呈负相关性(P均<0.05),而3 h的Ktrans值与30天的VCS评分无相关性(P=0.064);局部病灶区在外伤后1天和3天的ADC值与30天的VCS评分存在正相关(P均<0.05)。在病灶周围区,外伤后1天的Ktrans值与30天的VCS评分呈负相关(P<0.05),而3天的Ktrans值与30天的VCS评分无相关性(P=0.078);病灶周围区在外伤后3天的ADC值与30天的VCS评分呈负相关(P<0.05),而1天和7天的ADC值与30天的VCS评分无相关性(P=0.085、0.057)。结论 外伤后急性期的MRI定量测定能够预测预后。 |
| 英文摘要: |
| Objective To explore the value of the quantification of blood-brain barrier and cytotoxic edema at the early period after traumatic brain injury (TBI) in prediction of the neurofunction recovery related to hyperbaric oxygen (HBO) treatment. Methods Twenty-one rabbits were randomly divided into TBI+HBO group (n=15) and sham+HBO group (n=6). The TBI+HBO group received TBI induced by a modified weight drop device and sham+HBO group received no TBI. Both groups received a total of 10 times HBO treatments within 7 days after TBI. MRI was performed at 3 h, 1 day, 3 days, 7 days, 30 days after TBI. Also the standardized veterinary coma scale (VCS) was performed on pre-TBI, 1 day and 30 days after TBI. Results The VCS score of TBI+HBO group at 1 day and 30 days were both lower than pre-TBI (P=0.001), but the VCS score at 30 days was higher than 1 day (P=0.001). The volume transfer coefficient (Ktrans) value at 1 day and 3 days in the focal lesion area were negative correlated with the VCS score at 30 days (both P<0.05), but there was no correlation at 3 h with VCS score at 30 days (P=0.064). And the ADC value at 1 day and 3 days in the focal lesion area were positive correlated with the VCS score at 30 days (both P<0.05). The Ktrans value at 1 day in the perifocal area was negative correlated with the VCS score at 30 days (P<0.05), but there was no correlation at 3 days with VCS score at 30 days (P=0.078). The ADC value at 3 day in the perifocal area were negative correlated with the VCS score at 30 days (P<0.05), and there were no correlation at 1 day and 7 days with VCS score at 30 days (P=0.085, 0.057). Conclusion The quantification of focal lesion and perifocal areas at the acute phase after TBI can predicte the functional outcome. |
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