| 史丹丹,陈莉,罗天友,方维东,马超豪.慢性丘脑梗死患者全脑灰质体积改变及与认知功能减退的关系[J].中国医学影像技术,2016,32(5):683~687 |
| 慢性丘脑梗死患者全脑灰质体积改变及与认知功能减退的关系 |
| Correlation between gray matter volume changes and cognitive impairment in chronic thalamus infarction patients |
| 投稿时间：2015-09-11 修订日期：2015-12-10 |
| DOI：10.13929/j.1003-3289.2016.05.012 |
| 中文关键词: 丘脑 脑梗死 灰质 认知功能 磁共振成像 |
| 英文关键词:Thalamus Infarction Grey matter Cognitive function Magnetic resonance imaging |
| 基金项目:国家临床重点专科建设项目(国卫办医函[2013]544号)。 |
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| 中文摘要: |
| 目的 探讨慢性丘脑梗死患者全脑灰质体积改变及与认知功能减退的关系。方法 对26例慢性丘脑梗死患者(梗死组)和29名健康志愿者(对照组)进行神经心理学评价及MR扫描。分别计算全脑灰质、白质、丘脑梗死体积,并进行统计学分析。结果 与对照组比较,梗死组简易精神状态检查量表(MMSE)评分、短延迟回忆、长延迟回忆、再确认及图形回忆评分均明显降低(P均<0.05);梗死组全脑灰质体积与对照组比较明显减小[梗死组:(774291.49±42370.85)mm3,对照组(802999.21±37075.84)mm3,t=2.442,P=0.018]。梗死组全脑白质体积与对照组比较,差异无统计学意义[(705587.51±32886.53)mm3,(717580.47±31911.05)mm3,t=1.634,P=0.108]。梗死组全脑灰质体积与MMSE评分及图形回忆评分呈中度正相关(r=0.491、0.427,P=0.017、0.042);全脑灰质体积与短延迟回忆、长延迟回忆、再确认评分均无相关性(P均>0.05);丘脑梗死体积与全脑灰质体积、MMSE评分、短延迟回忆、长延迟回忆、再确认及图形回忆评分均无相关性(P均>0.05)。结论 慢性丘脑梗死患者全脑灰质体积减小,可能是其认知功能减退的原因。 |
| 英文摘要: |
| Objective To explore the correlation between gray matter volume changes and cognitive impairment in chronic thalamus infarction patients.Methods Totally 26 patients with chronic thalamic infarction (infarction group) and 29 healthy volunteers (control group) underwent neuropsychological test and MR scan. The volume of whole brain gray matter, whole brain white matter and thalamus infarction were calculated and statistical analysis was performed.Results Compared with control group, the scores of mini-mental state examination (MMSE), short-term memory, long-term memory, reconfirm and figure recall all significantly decreased in infarction group (all P<0.05); the whole brain gray matter volume significantly decreased in infarction group ([774 291.49±42 370.85] mm3 vs[802 999.21±37 075.84]mm3, t=2.442, P=0.018). There was no significant difference in whole white matter volume in[JP] infarction group ([705 587.51±32 886.53]mm3) compared with that in control group ([717 580.47±31 911.05]mm3, t=1.634, P=0.108). There was a moderate positive association between whole brain gray matter volume and the scores of MMSE and figure recall (r=0.491, 0.427, P=0.017, 0.042), but no relationship between whole brain gray matter volume and the scores of short-term memory, long-term memory, reconfirm (all P>0.05). There was no significant relationship between thalamus infarction volume and whole brain gray matter volume, the scores of MMSE, short-term memory, long-term memory, reconfirm and figure recall (all P>0.05).Conclusion The whole brain gray matter volume decreases in chronic thalamic infarction patients, which may be the reason for cognitive impairment. |
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