| 王梦星,雷都,张慧,张记磊,张凯华,马骏,杜小霞.注意缺陷型和混合型注意缺陷多动障碍儿童在Go/Nogo任务中的脑fMRI[J].中国医学影像技术,2016,32(5):678~682 |
| 注意缺陷型和混合型注意缺陷多动障碍儿童在Go/Nogo任务中的脑fMRI |
| Brain fMRI in combined and inattentive subtypes of attention deficit hyperactivity disorder during Go/Nogo task |
| 投稿时间：2015-09-23 修订日期：2016-01-28 |
| DOI：10.13929/j.1003-3289.2016.05.011 |
| 中文关键词: 注意缺陷多动障碍 脑 功能磁共振成像 |
| 英文关键词:Attention deficit disorder with hyperactivity Brain Functional magnetic resonance imaging |
| 基金项目:国家自然科学基金(81201082、81571658)、上海市科学技术委员会2014年医学引导类基金(14411969200)。 |
|
| 摘要点击次数: 3016 |
| 全文下载次数: 935 |
| 中文摘要: |
| 目的 探讨注意缺陷多动障碍(ADHD)注意缺陷型(ADHD-I)、混合型(ADHD-C)以及健康儿童在经典Go/Nogo抑制控制任务中脑功能激活的异同。方法 对19例ADHD-I(ADHD-I组)、21例ADHD-C(ADHD-C组)和25名健康儿童(HC组)进行Go/Nogo任务fMRI,采用SPM8软件处理功能数据,比较3组反应抑制和错误加工激活脑区的差异。结果 3组反应抑制差异的脑区主要位于左侧额下回和右侧额中回,ADHD-C在左侧额下回的脑激活水平高于ADHD-I(P<0.001);3组错误加工差异脑区主要位于右侧额上回,而ADHD-C组与ADHD-I组激活脑区差异无统计学意义(P=1.000)。结论 ADHD儿童在Go/Nogo任务中表现出的抑制控制脑功能受损,且ADHD-I和ADHD-C的反应抑制受损程度不同。 |
| 英文摘要: |
| Objective To compare the differences of brain function among children with combined attention deficit hyperactivity disorder (ADHD-C), inattentive ADHD (ADHD-I) and healthy controls during classical Go/Nogo task. Methods Totally 19 ADHD-I children (ADHD-I group), 21 ADHD-C children (ADHD-C group) and 25 healthy participants (HC group) underwent fMRI while performing the Go/Nogo task. Functional brain images were analyzed with the Statistical Parametric Mapping (SPM8) software. The activating brain area of response inhibition and error processing were compared among three groups. Results During response inhibition, significant differences of activating brain area among three groups were observed in left inferior frontal gyrus and right middle frontal gyrus, and ADHD-C group showed greater activation than ADHD-I group in inferior frontal gyrus (P<0.001). During error processing, significant differences of activating brain area among three groups were observed in right superior frontal gyrus, while there was no significant difference between ADHD-I group and ADHD-C group. Conclusion The children with ADHD-I and ADHD-C show dysfunctional inhibition control when performing Go/Nogo task, and the degree of dysfunctional inhibition control is different between ADHD-C and ADHD-I. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
