| 陈晓飞,俞万钧,马坚.CT诊断肺动脉高压Meta分析[J].中国医学影像技术,2016,32(3):385~388 |
| CT诊断肺动脉高压Meta分析 |
| CT diagnosis of pulmonary arterial hypertension: Meta-analysis |
| 投稿时间：2015-03-12 修订日期：2015-07-01 |
| DOI：10.13929/j.1003-3289.2016.03.017 |
| 中文关键词: 肺动脉高压 体层摄影术,X线计算机 Meta分析 |
| 英文关键词:Pulmonary arterial hypertension Tomography, X-ray computed Meta-analysis |
| 基金项目:2012年度宁波市第三批科技项目(2012C91022)。 |
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| 中文摘要: |
| 目的 采用Meta分析评价CT在肺动脉高压中的诊断价值。方法 通过检索Pubmed、Elsevier和中国期刊网数据库(CNKI),获得相关中、英文文献,采用QUADAS-2工具对纳入的研究进行质量评价。采用Meta-disc 1.40软件对纳入的文献进行异质性检验,根据随机效应模型,汇总敏感度、特异度,并绘制综合受试者工作特征(SROC)曲线,计算曲线下面积。结果 共12篇文献符合要求,纳入其中8篇文献、均以肺动脉直径/升主动脉直径>1或≥1作为肺动脉高压的诊断标准,纳入对象共计1111例。Deeks漏斗图分析提示各文献间无明显发表偏倚(P=0.501)。汇总后的敏感度、特异度分别为74%(95%可信区间:70%~77%)、81%(95%可信区间:76%~85%),SROC曲线下面积为0.8535。结论 CT检查肺动脉直径/主动脉直径诊断肺动脉高压具有一定的临床应用价值。 |
| 英文摘要: |
| Objective To explore the value of CT in the diagnosis of pulmonary arterial hypertension with a Meta-analysis. Methods A comprehensive search for Pubmed, Elsevier, and China National Knowledge Infrastructure(CNKI) was performed to acquire relevant English and Chinese articles, and the quality of included studies was assessed using the QUADAS-2 tool. The heterogeneity of the included articles was tested with software Meta-disc 1.40. According to the random effects model, the sensitivity and specificity were calculated, and the summary receiver operating characteristic(SROC) curve was performed and then the area under the curve(AUC) was calculated. Results There were twelve studies meet the requirement and eight articles which use the ratio of pulmonary artery diameter/aorta diameter>1 or ≥1 as the diagnostic criteria of pulmonary artery hypertension were finally included, a total of 1 111 cases were included. Deeks funnel plot suggested the publication bias was not significant(P=0.501). The sensitivity and specificity was 74%(95%CI 70%-77%), 81%(95%CI 76%-85%), respectively. The AUC of SROC curve was 0.853 5. Conclusion CT has a certain clinical value in the diagnosis of pulmonary hypertension using the ratio of pulmonary artery diameter/aortic diameter. |
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