| 聂晓,彭德昌,李海军,戴西件,万爱兰,聂思,刘雪琴.原发性失眠的不同频段低频振幅静息态功能磁共振研究[J].中国医学影像技术,2016,32(2):204~208 |
| 原发性失眠的不同频段低频振幅静息态功能磁共振研究 |
| Frequency-dependent alterations in amplitude of low-frequency fluctuations in primary insomnia:Resting-state fMRI study |
| 投稿时间：2015-05-06 修订日期：2015-10-30 |
| DOI：10.13929/j.1003-3289.2016.02.011 |
| 中文关键词: 原发性失眠 磁共振成像 低频振幅 |
| 英文关键词:Primary insomnia Magnetic resonance imaging Low-frequency fluctuation |
| 基金项目:国家自然科学基金(81560285)、江西省科技支撑计划(20132BBG70061、20141BBG70026、20121BBG70056)、江西省自然科学基金(20132BAB205100)。 |
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| 中文摘要: |
| 目的 应用静息态低频振幅算法探讨原发性失眠(PI)患者在不同频段(Slow-4:>0.027~0.073 Hz,Slow-5:0.01~0.027 Hz)大脑自发活动的变化。方法 44例PI患者(PI组)及44名年龄、性别匹配的正常睡眠志愿者(对照组)均接受fMRI扫描,应用静息态fMRI数据处理助手(DPARSFA)进行数据预处理,SPM8软件包进行全因素方差分析PI组和对照组及不同频段脑功能活动特点。之后,对PI组和对照组采用两样本t检验分别观察两个频段ALFF值差异,同时分析ALFF值差异脑区与临床量表的相关性。结果 不同频段间一些脑区的ALFF值存在差异,包括双侧尾状核头、双侧岛叶、双侧颞上回、双侧内侧额叶、双侧眶额皮质、双侧颞下回(P<0.01,AlphaSim校正)。与对照组相比,PI组双侧小脑后叶、左侧额上回、内侧额叶ALFF减低,而左侧颞中回、右侧颞上回、双侧后扣带回、双侧楔前叶ALFF增高(P<0.01,AlphaSim校正)。此外,Slow-5频段更容易发现PI患者异常的大脑自发活动。结论 PI患者存在多个脑区神经元的自发活动异常且具有频率相关性。 |
| 英文摘要: |
| Objective To investigate the features of resting-state brain activity in amplitude of low-frequency fluctuation (ALFF) within different band of fluctuation (Slow-4:>0.027-0.073 Hz;Slow-5:0.01-0.027 Hz) in primary insomnia (PI group) patients.Methods Totally 44 PI patients and 44 age-,gender-,and education-matched good sleepers (GS group) were recruited and underwent R-fMRI scans.The data processing was performed using DPARSFA,measures ANOVA with condition (PI,GS) and frequency band (Slow-4,Slow-5) were performed using SPM8 to analyze the features of intrinsic brain activity,post-hoc analysis were used to observe the ALFF value between two groups in frequency bands of Slow-4 and Slow-5,and the correlations between significant ALFF values and clinical markers.Results There showed a significant ALFF value between the two bands in some regions including bilateral caudate head,bilateral insula,bilateral inferior temporal gyrus,bilateral medial frontal gyrus,bilateral orbitofrontal cortex,bilateral superior temporal gyrus (P<0.05,AlphaSim corrected).Compared with GS group,PI group showed decreasing ALFF in the bilateral cerebellum posterior lobe,left superior frontal gyrus,medial frontal gyrus;and increasing ALFF in the left middle temporal gyrus,right superior temporal gyrus,bilateral posterior cingulate,bilateral precuneus (P<0.05,AlphaSim corrected).Furthermore,the Slow-5 frequency band were more likely to find abnormal spontaneous brain activity in PI group.Conclusion PI patients has abnormal neurons intrinsic brain activity in many brain regions and Slow-5 band is more specific for PI. |
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