| 姜利伶,赵建农,周治明,吴伟,李小风,姜柳米.小脑顶核电刺激对阿尔茨海默病磁共振波谱代谢物的影响[J].中国医学影像技术,2016,32(2):183~186 |
| 小脑顶核电刺激对阿尔茨海默病磁共振波谱代谢物的影响 |
| Influence of fastigial nucleus electrostimulation on metabolites for magnetic resonance spectroscopy in Alzheimer disease |
| 投稿时间：2015-07-09 修订日期：2015-11-15 |
| DOI：10.13929/j.1003-3289.2016.02.006 |
| 中文关键词: 阿尔茨海默病 神经核团 神经电刺激 磁共振波谱 |
| 英文关键词:Alzheimer disease Cerebellar Nuclei Transcutaneous electric nerve stimulation Magnetic resonance spectroscopy |
| 基金项目:国家自然科学基金面上项目(81071126)。 |
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| 摘要点击次数: 2471 |
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| 中文摘要: |
| 目的 采用MRS评价小脑顶核电刺激(FNS)对阿尔茨海默病(AD)患者后扣带回(PCC)代谢物的影响。方法 收集AD患者36例,随机分为治疗组和安慰组,各18例。治疗组给予小脑FNS治疗。治疗前、后采用MRS评估PCC代谢产物N-乙酰天门冬氨酸(NAA)/肌酸(Cr)值、肌醇(mI)/Cr值。比较两组治疗前、后代谢物的差异。结果 治疗组治疗后NAA/Cr值较治疗前轻度升高,但差异无统计学意义(P>0.05),mI/Cr值较治疗前降低,差异有统计学意义(t=-2.502,P<0.05);治疗后治疗组NAA/Cr值较安慰组升高,mI/Cr值降低,差异均有统计学意义(t=4.176、-4.987,P均<0.05)。结论 FNS治疗后AD大脑代谢物发生了变化,MRS可作为观察AD的客观辅助手段。 |
| 英文摘要: |
| Objective To assess the metabolite alteration of posterior cingulated cortex (PCC) in Alzheimer disease (AD) patients after therapy of fastigial nucleus electrostimulation (FNS) with MRS.Methods Thirty-six AD patients were randomly divided into treatment group and control group (each n=18).FNS was used to the treatment group.The ratios of N-Acetyl L-Aspartic acid (NAA)/Creatine (Cr) and Myo-inositol (mI)/Cr of PCC were assessed with MRS.The differences of metabolites in two groups before and after treatment were compared.Results Post-therapeutic ratio of NAA/Cr in treatment group increased slightly (P>0.05),mI/Cr was lower than the pre-therapeutic (t=-2.502,P<0.05).Compared with control group,NAA/Cr in treatment group increased,mI/Cr decreased,which were statistically significant differences (t=4.176,-4.987,all P<0.05).Conclusion The brain metabolites are altered in patients with AD after FNS.MRS is a useful and objective tool for observing AD. |
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