| 刘萌,廖栩鹤,王荣福,张建华,陈雪祺,付占立,范岩,张旭初,赵光宇.18F-FDG PET/CT在弥漫大B细胞淋巴瘤免疫亚型诊断中的应用[J].中国医学影像技术,2016,32(1):75~78 |
| 18F-FDG PET/CT在弥漫大B细胞淋巴瘤免疫亚型诊断中的应用 |
| Application of 18F-FDG PET/CT in diffuse large B-cell lymphoma immunological subtyping |
| 投稿时间：2015-04-21 修订日期：2015-09-26 |
| DOI：10.13929/j.1003-3289.2016.01.020 |
| 中文关键词: 淋巴瘤,大型B细胞,弥散 体层摄影术,发射型计算机 氟脱氧葡萄糖F18 |
| 英文关键词:Lymphoma,large B-cell,diffuse Tomography,emission-computed Fluorodeoxyglucose F 18 |
| 基金项目:国家自然科学基金(NSFC30900374、81071183)。 |
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| 中文摘要: |
| 目的 探讨18F-FDG PET/CT在弥漫大B细胞淋巴瘤(DLBCL)免疫亚型诊断中的应用价值。方法 回顾性分析69例在本院初诊DLBCL患者的18F-FDG PET/CT表现。观察生发中心B细胞样(GCB)和非生发中心(non-GCB)的18F-FDG PET/CT表现特征;分析不同免疫亚型PET/CT影像指标 、临床特征(Ann Arbor分期、临床症状、性别、年龄)及核抗原Ki-67的差异。结果 18F-FDG PET/CT显示,单发病灶12例(12/69,17.39%),多发病灶57例(57/69,82.61%)。DLBCL病灶SUVmax为11.80(8.80)。不同免疫亚型的病灶SUVmax (Z=-0.03)、 Ki-67(t=0.03)、PET/CT病灶数(χ2=0.06)、Ann Arbor分期(χ2=3.48)、临床症状(χ2=0.49)、性别 (χ2=1.62)、年龄(r=-0.21)比较,差异均无统计学意义(P均>0.05)。SUVmax与Ki-67呈正相关(r=0.38,P<0.05)。结论 18F-FDG SUVmax可预测DLBCL的增殖情况及侵袭程度。 |
| 英文摘要: |
| Objective To evaluate the application value of 18F-FDG PET/CT in diffuse large B-cell lymphoma (DLBCL) immunological subtyping. Methods Sixty-nine patients who underwent 18F-FDG PET/CT imaging for newly diagnosed DLBCL were retrospectively reviewed. The 18F-FDG PET/CT imaging performances of germinal center B-cell like (GCB) and non-GCB immunological subtypes were observed. The difference of immunological subtypes with PET/CT imaging indexes (maximum of standard uptake value, lesion numbers), clinical characteristics (Ann Arbor stage, clinical symptoms, gender, age), and Ki-67 was analyzed, respectively. Results Twelve cases (12/69, 17.39%) were presented with single lesion, and fifty-seven cases (57/69, 82.61%) were multiple lesions. SUVmax of DLBCL lesions was 11.80 (8.80). In different immunological subtypes, in SUVmax (Z=-0.03), Ki-67 (t=0.03), PET/CT lesion numbers (χ2=0.06), Ann Arbor stage (χ2=3.48), clinical symptoms (χ2=0.49), gender (χ2=1.62), and age (r=-0.21) had not any statistical difference (all P>0.05). Significantly positive correlation of SUVmax and Ki-67 was observed (r=0.38, P<0.05). Conclusion 18F-FDG SUVmax can predict the proliferation condition and invasive degree of DLBCL. |
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