| 肖友平,陈韵彬,潘建基,陈英,何庄贞,任旺.体素内不相干运动扩散加权成像技术在鼻咽肿瘤的可重复性和诊断应用[J].中国医学影像技术,2015,31(12):1801~1805 |
| 体素内不相干运动扩散加权成像技术在鼻咽肿瘤的可重复性和诊断应用 |
| Reproducibility of Intravoxel incoherent motion diffusion weighted imaging and diagnostic application in nasopharyngeal neoplasms |
| 投稿时间：2015-05-07 修订日期：2015-09-29 |
| DOI：10.13929/j.1003-3289.2015.12.008 |
| 中文关键词: 鼻咽肿瘤 体素内不相干运动 扩散磁共振成像 可重复性 |
| 英文关键词:Nasopharyngeal neoplasms Intravoxel incoherent motion Diffusion magnetic resonance imaging Reproducibility |
| 基金项目:福建省卫生青年课题(2014-1-14)。 |
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| 中文摘要: |
| 目的 评估体素内不相干运动扩散加权成像(IVIM-DWI)技术在鼻咽部肿瘤的可重复性及其诊断价值。方法 对18名志愿者(正常对照组)和40例可疑鼻咽占位者(鼻咽良性增生组10例,鼻咽淋巴瘤组17例,鼻咽癌组13例)隔天重复行鼻咽IVIM-DWI扫描,经后处理分析和测量得到相应的IVIM参数值:真实扩散系数(D值)、灌注相关扩散系数(D*值)和灌注相关扩散分数(f值)。采用组内相关系数(ICC)检验参数的可重复性;单因素方差分析比较各组间的参数值差异。结果 正常对照组观察者间和观察者内ICC值分别为0.872和0.929、0.919和0.928、0.855和0.939,鼻咽占位患者相应ICC值为0.968和0.97、0.858和0.958、0.853和0.978。鼻咽癌组较正常对照组和良性增生组具有更高的D*值和更低的D值(P<0.05);淋巴瘤组的D和D*值均低于其余3组(P均<0.05);各组间的f值差异均无统计学意义(P均>0.05)。D值诊断淋巴瘤和鼻咽癌的阈值分别为0.879×10－3 mm2/s和0.883×10－3 mm2/s,D*值分别为68.070×10－3 mm2/s和120.100×10－3 mm2/s;D值和D*值鉴别淋巴瘤和鼻咽癌的阈值分别为0.713×10－3 mm2/s和87.750×10－3 mm2/s。结论 IVIM-DWI在鼻咽部具有良好的可重复性,对鼻咽肿瘤具有较高的鉴别诊断价值。 |
| 英文摘要: |
| Objective To evaluate the reproducibility of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) on nasopharynx and its value in differentiating nasopharyngeal neoplasms. Methods Totally 18 volunteers (control group) and 40 patients with nasopharyngeal neoplasms, including benign hyperplasia group (n=10), lymphoma group (n=17), nasopharyngeal carcinoma group (n=13) were enrolled and scanned with IVIM-DWI repeatedly at the alternate days. IVIM-derived parameters of pure diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f) were calculated. The intra- and inter-observer agreement of parameters were tested with intraclass correlation coefficient (ICC). The parameters between different groups were also compared. Results In control group, the inter- and intra-observer ICCs were 0.872 and 0.929, 0.919 and 0.928, 0.855 and 0.939; while those of nasopharynx neoplasms were 0.968 and 0.97, 0.858 and 0.958, 0.853 and 0.978, respectively. In nasopharyngeal carcinoma group, D was higher and D* was lower than those in control group and nasopharyngeal benign hyperplasia group (P<0.05). In lymphoma group, D* and D were significantly lower than those in the other three groups (all P<0.05). f values were not significantly different between any two groups (all P>0.05). In diagnosis of lymphoma and nasopharyngeal carcinoma, the thresholds of D value were 0.879×10－3 mm2/s and 0.883×10－3 mm2/s, which of D* values were 68.070×10－3 mm2/s and 120.100×10－3 mm2/s. In identifying lymphoma and nasopharyngeal carcinoma, the thresholds of D and D* values were 0.713×10－3 mm2/s and 87.750×10－3 mm2/s. Conclusion IVIM-DWI is reproducible on nasopharynx and valuable in diagnosis of nasopharynx neoplasms. |
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