| 蔡兆熙,李永,杨泽宏,龚苏,张梦迪,陈建宇.宫颈癌放疗后骨盆衰竭骨折MRI及相关临床特点分析[J].中国医学影像技术,2015,31(10):1483~1486 |
| 宫颈癌放疗后骨盆衰竭骨折MRI及相关临床特点分析 |
| MRI and associated clinical characteristics of pelvic insufficiency fracture in cervical carcinoma patients after radiation therapy |
| 投稿时间：2015-03-14 修订日期：2015-06-24 |
| DOI：10.13929/j.1003-3289.2015.10.009 |
| 中文关键词: 骨折,应力性 骨盆 放射疗法 子宫颈肿瘤 磁共振成像 |
| 英文关键词:Fractures, stress Pelvis Radiotherapy Uterine cervical neoplasms Magnetic resonance imaging |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨宫颈癌放疗后骨盆衰竭骨折的MRI特点、骨折率及相关因素。方法 收集176例具有完整临床及盆腔MRI资料的宫颈癌放疗后患者,分为衰竭骨折组及未骨折组,进行统计学分析。结果 176例中,发生骨盆衰竭骨折共15例(15/176,8.52%)。衰竭骨折组与未骨折组间宫颈癌首诊时年龄、月经状况、放疗治疗方式及是否适合手术治疗方面差异均有统计学意义(P均<0.05)。两组间体质量指数、FIGO分期、盆腔外放疗的辐射剂量、放疗结束至MR检查的时间间隔差异均无统计学意义(P均>0.05)。MRI示15例均累及骶骨,其中4例同时合并第1或2骶椎横行骨折,3例同时累及耻骨或髂骨。Kaplan-Meier曲线图示衰竭骨折5年累积发病率为31.80%。结论 宫颈癌放疗后骨盆衰竭骨折好发于骶骨,高龄和绝经状态是其主要危险因素。 |
| 英文摘要: |
| Objective To assess MRI, clinical characteristics, incidence and risk factors of pelvic insufficiency fracture (IF) in cervical carcinoma patients after radiation therapy. Methods Totally 176 cervical carcinoma patients underwent pelvic radiation therapy. All the cases were divided into IF group and non-fracture group. The statistical analysis was performed. Results Pelvic IF was found in 15 cases (15/176, 8.52%). There were statistical differences of age, menstrual status, radiotherapy mode (only radiotherapy or radiotherapy combined with surgery) and the situation of whether suitable for surgery between the two groups (all P<0.05). No statistical difference of body mass index, FIGO staging, external pelvic radiation dose, the interval of radiation to the last MR scan was found between IF group and non-fracture group (all P>0.05). Fractures involved sacrum in all of 15 cases. There were 4 cases combined with the first or second sacral vertebrae transverse fractures and 3 cases combined with pubis or iliac crest fractures. Kaplan-Meier curve showed the 5 years fractures cumulative incidence was 31.80%. Conclusion Most of pelvic IF occurs in sacrum after radiotherapy for cervical carcinoma. Elder and menopausal status are the main risk factors of IF. |
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