| 陆雪芳,伍建林.H-MRS在2型糖尿病脑损伤的研究进展[J].中国医学影像技术,2015,31(9):1418~1421 |
| H-MRS在2型糖尿病脑损伤的研究进展 |
| Progresses of 1H magnetic resonance spectroscopy in evaluation of type 2 diabetes brain damage |
| 投稿时间：2015-01-06 修订日期：2015-07-08 |
| DOI：10.13929/j.1003-3289.2015.09.035 |
| 中文关键词: 糖尿病 磁共振波谱成像 神经化学代谢物 |
| 英文关键词:Diabetes mellitus Magnetic resonance spectroscopy Neurochemical metabolites |
| 基金项目:国家自然科学基金(81371526). |
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| 中文摘要: |
| 糖尿病(DM)是以血糖升高为特征的伴随多系统并发症的综合性代谢疾病,中枢神经系统是最易受累的部位之一.早期发现DM所致的大脑微结构损伤以及神经生理、代谢活动等改变已成为近年来的研究热点.1H-MRS是唯一活体检测人脑多种代谢物变化的较敏感的无创性方法,并有望成为诊断与评估DM脑微结构损伤的敏感性生物学指标.本文从临床和基础研究两方面对1H-MRS评价DM患者脑微结构及功能性改变的价值进行综述. |
| 英文摘要: |
| Diabetes mellitus is a kind of systematic metabolic disease, which is usually characterized by hyperglycemia and accompanied with multi-system complications. Central nervous system is one of the most involvement systems. Diagnosing DM associated cerebral neurophysiologic and structural changes have became the focus of current researches. 1H-MRS is the only noninvasive and sensitive technique which can provide information on the anatomical, functional and metabolic aspects of the brain. It may be a promising biological marker for diagnosis and evaluation on brain structural damage. This review focused on the value of 1H-MRS on evaluating the changes of anatomical, functional and metabolic aspects of the brain damage based on clinical and basic researches. |
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