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肖翔,许乙凯,代月黎,李维粤,陈婉琪,吴元魁.¹H-MRS评价颞叶癫痫患者杏仁核代谢物比值[J].中国医学影像技术,2015,31(9):1300~1303

¹H-MRS评价颞叶癫痫患者杏仁核代谢物比值

¹H-MRS evaluation of metabolite ratios of amygdala in temporal lobe epilepsy patients

投稿时间：2015-03-09 修订日期：2015-08-05

DOI：10.13929/j.1003-3289.2015.09.004

中文关键词: 颞叶癫痫杏仁核磁共振波谱成像

英文关键词:Temporal lobe Epilepsy Amygdala Magnetic resonance spectroscopy

基金项目:

作者	单位
肖翔	南方医科大学南方医院影像中心, 广州 510515
许乙凯	南方医科大学南方医院影像中心, 广州 510515
代月黎	南华大学附属第二医院放射科, 衡阳 421001
李维粤	南方医科大学南方医院影像中心, 广州 510515
陈婉琪	南方医科大学南方医院影像中心, 广州 510515
吴元魁	南方医科大学南方医院影像中心, 广州 510515

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中文摘要:

目的采用¹H-MRS探讨颞叶癫痫(TLE)患者双侧杏仁核的各代谢物比值改变.方法对15例TLE患者(TLE组)和15名健康志愿者(正常对照组)行杏仁核¹H-MRS扫描,比较两组杏仁核的N-乙酰天门冬氨酸(NAA)/、NAA/Cr、NAA/Cho和Cho/Cr比值,分析TLE患者双侧杏仁核各代谢物比值与癫痫病程和发病年龄的相关性.结果 TLE组患侧杏仁核NAA/(Cho+Cr)和NAA/Cr比值与正常对照组比较均明显减低(P均 <0.05);TLE组患侧杏仁核NAA/(Cho+Cr)、NAA/Cr、NAA/Cho和Cho/Cr比值与TLE组对侧比较差异均无统计学意义(P均 >0.05);TLE组对侧杏仁核NAA/(Cho+Cr)、NAA/Cr和NAA/Cho比值与正常对照组比较均明显减低(P均 <0.05).TLE组双侧杏仁核NAA/(Cho+Cr)、NAA/Cr和NAA/Cho比值与癫痫病程及发病年龄均无相关性(P均 >0.05).结论 TLE患者双侧杏仁核存在显著的代谢异常,双侧杏仁核可能作为传导通路的一个环节,参与TLE的发病过程.

英文摘要:

Objective To investigate the metabolite ratios changes of bilateral amygdala in TLE patients with ¹H-MRS. Methods Fifteen TLE patients (TLE group) and 15 healthy volunteers (control group) were performed ¹H-MRS of amygdala. The ratios of N-acetylaspartate (NAA)/(choline+creatine), NAA/Cr, NAA/Cho and Cho/Cr of amygdala between two groups were compared. The correlation between the duration of epilepsy, the age of onset and the ratios of NAA/(Cho+Cr), NAA/Cr and NAA/Cho in bilateral amygdala of TLE group were analyzed. Results The ratios of NAA/(Cho+Cr) and NAA/Cr in ipsilateral amygdale of TLE group were significant lower than those of control group (both P <0.05). There were no significant differences in the ratios of NAA/(Cho+Cr), NAA/Cr, NAA/Cho or Cho/Cr between bilateral amygdala of TLE group (all P >0.05). The ratios of NAA/(Cho+Cr), NAA/Cr and NAA/Cho in the contral lateral amygdale of TLE group was significant lower than those of control group (all P <0.05). The ratios of NAA/(Cho+Cr), NAA/Cr and NAA/Cho in bilateral amygdala of TLE group had no correlation with the duration of epilepsy or the age of onset (all P >0.05). Conclusion TLE patients have significant metabolic changes in bilateral amygdala, and bilateral amygdala may serve as a link of the conductive pathway, involving in the pathogenesis of TLE.

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