| 杨军,李勤勍,丁莹莹,李卓琳,封俊,王关顺,廖承德.锰离子增强MRI在显示大鼠视觉传导通路中的最佳时间[J].中国医学影像技术,2015,31(9):1295~1299 |
| 锰离子增强MRI在显示大鼠视觉传导通路中的最佳时间 |
| Manganese-enhanced MRI in evaluation on optimal imaging time for optic nerve and central nucleus in rat |
| 投稿时间：2014-12-17 修订日期：2015-02-26 |
| DOI：10.13929/j.1003-3289.2015.09.003 |
| 中文关键词: 锰 磁共振成像 视神经 视觉核团 |
| 英文关键词:Manganese Magnetic resonance imaging Optic nerve Visual nuclei |
| 基金项目:国家自然地区科学基金(81260408)、云南省科技厅-昆明医科大学应用基础研究联合专项(2012FB061、2014FB061)、云南省肿瘤医院博士启动基金(BSJJ201409). |
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| 中文摘要: |
| 目的 探讨锰离子增强MRI在显示大鼠视觉传导通路中的最佳时间.方法 对24只SD大鼠的单侧眼球内注射氯化锰溶液(30 mmol/L)3 μl后,随机分为8组(注射后3、6、12、24、30、36、48、72 h组),在间隔不同时间后分别行MR T1W扫描.设定相同的ROI后,分别测量和计算视神经、外侧膝状体、上丘在各组图像中的CNR.结果 3~24 h视神经、外侧膝状体和上丘的MR强化信号逐渐增高,至24 h达峰值,持续至30 h后逐渐下降.大鼠视神经的信号强度除在注射后6 h组和72 h组、24 h组和30 h组差异无统计学意义外(P均 >0.05),其余各组间的差异均有统计学意义(P均 <0.05);外侧膝状体各组间两两比较、上丘各组间两两比较差异均有统计学意义(P均 <0.05).结论 锰离子增强MRI在显示大鼠视觉传导通路中的最佳时间是24~30 h. |
| 英文摘要: |
| Objective To explore manganese-enhanced MRI (MEMRI) in evaluation on optimal imaging time of rat visual projections. Methods Totally 24 SD rats of unilateral intra-vitreal injection of MnCl2(30 mmol/L×3 μl) underwent MEMRI, and were randomly divided into 8 groups: 3 h, 6 h, 12 h, 24 h, 30 h, 36 h, 48 h, 72 h group. The signal intensity (SI) and CNR of the optic nerve (ON), lateral geniculate nucleus (LGN) and superior colliculus (SC) were calculated. Results The CNR of ON, LGN and SC increased from 3 h to 24 h and enhanced to the peak at 24 h, but the CNR declined gradually at 30 h since the injection. The CNR differences of ON among eight groups was significant (all P <0.05) except for its between 6 h group and 72 h group, 24 h group and 30 h group (both P >0.05). CNR differences of LGN and SC between each two groups had statistically significance (all P <0.05). Conclusion The optimal time of MEMRI in rat visual projections is 24 h to 30 h after MnCl2 intravitreal injections. |
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