| 史勇跃,游忠岚,王健,潘春燕,刘晶磊,张久权,崔进国.肝硬化患者脑灰质结构的纵向MRI改变[J].中国医学影像技术,2015,31(8):1163~1167 |
| 肝硬化患者脑灰质结构的纵向MRI改变 |
| Longitudinal MRI changes of brain gray matter in hepatic cirrhosis patients |
| 投稿时间：2014-12-23 修订日期：2015-04-08 |
| DOI：10.13929/j.1003-3289.2015.08.010 |
| 中文关键词: 肝硬化 纵向研究 基于体素的形态学分析 磁共振成像 |
| 英文关键词:Liver cirrhosis Longitudinal study Voxel-based morphometry Magnetic resonance imaging |
| 基金项目:河北省自然科学科学基金(H2014505007)。 |
| 作者 | 单位 | E-mail | | 史勇跃 | 白求恩国际和平医院放射科, 河北 石家庄 050082
中国人民解放军第37医院放射科, 四川 雅安 625000
| | | 游忠岚 | 第三军医大学西南医院传染科, 重庆 400038
| | | 王健 | 第三军医大学西南医院放射科, 重庆 400038 | | | 潘春燕 | 白求恩国际和平医院放射科, 河北 石家庄 050082
| | | 刘晶磊 | 白求恩国际和平医院放射科, 河北 石家庄 050082
| | | 张久权 | 第三军医大学西南医院放射科, 重庆 400038 | | | 崔进国 | 白求恩国际和平医院放射科, 河北 石家庄 050082
| 崔进国,白求恩国际和平医院放射科,050082。E-mail: cuijinguo2005@163.com |
|
| 摘要点击次数: 2743 |
| 全文下载次数: 579 |
| 中文摘要: |
| 目的 探讨应用MRI评价肝硬化(HC)患者全脑灰质结构随时间变化的特征。方法 对15例单纯HC患者肝脏储备功能进行量化评估,并进行神经心理学测试及大脑结构MR扫描,间隔2年随访,采用SPM8基于体素的形态学方法进行结构数据处理。结果 纵向对比发现,维持有效治疗2年后,HC患者肝功能评分得以有效控制,但大脑双侧直回/眶回灰质体积明显缩小,而双侧中央前回灰质体积显著增大,且Child-Pugh评分和神经心理学测试评分减低。结论 随病程持续进展,HC患者大脑灰质体积的改变逐渐明显,其结构的改变可能是导致轻微肝性脑病发生发展的结构基础。 |
| 英文摘要: |
| Objective To explore the characteristics of structural abnormalities in the time-varying longitudinal course of hepatic cirrhosis (HC) patients with MRI. Methods Fifteen HC patients were enrolled to perform neuropsychological tests, quantitative assessment of hepatic function and structural MR scanning at baseline and again 2 years later. Gray matter changes over time were measured with voxel-based morphometry using SPM8. Results At the 2-year follow-up, it improved obviously in Child-Push scores, and decreased from baseline in neuropsychological tests of HC patients with maintenance therapy, and the alterations of gray matter volumes decreased in bilateral rectal gyrus/orbital gyrus, whereas increased significantly in bilateral precentral gyrus. Conclusion There are significant changes of gray matter volumes in specific regions of HC patients with disease progression, which may be associated with cognitive and neuropsychiatric impairment of minimal hepatic encephalopathy patients. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
