| 李新华,孟志华,杜日昌,程英,胡景皓,孙俊旗.乳腺浸润性导管癌时间-信号强度曲线及ADC值与病理学分级的相关性[J].中国医学影像技术,2015,31(7):1033~1036 |
| 乳腺浸润性导管癌时间-信号强度曲线及ADC值与病理学分级的相关性 |
| Correlation of time-signal intensity curve and ADC values with histopathologic classification in patients with invasive ductal carcinoma |
| 投稿时间：2015-01-07 修订日期：2015-05-08 |
| DOI：10.13929/j.1003-3289.2015.07.019 |
| 中文关键词: 癌,导管,乳腺 磁共振成像 动态增强 扩散磁共振成像 组织病理分级 |
| 英文关键词:Carcinoma, ductal, breast Magnetic resonance imaging Dynamic contrast enhanced Diffusion magnetic resonance imaging Histopathologic classification |
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| 中文摘要: |
| 目的 探讨浸润性导管癌(IDC)时间-信号强度曲线(TIC)及ADC值与组织学分级的相关性。方法 回顾性分析43例(共45个病灶)经病理学证实为IDC的动态增强MRI及DWI表现,测量肿块的早期强化率、ADC值,描绘时间-信号强度曲线(TIC),对不同病理学分级IDC的早期强化率、TIC曲线分型及ADC值进行组间比较,并分析其与病理组织分级的相关性。结果 43例IDC中,Ⅰ级8例,Ⅱ级24例,Ⅲ级11例。不同级别IDC两两比较,早期强化率的差异均无统计学意义(P均>0.05),而TIC曲线分型、ADC值的差异均有统计学意义(P均<0.05),IDC的TIC曲线分型与病理组织学分级呈正相关关系(r=0.40,P<0.01),与ADC值呈负相关(r=-0.79,P<0.01)。正常乳腺组织与不同病理组织分级IDC的ADC值差异均有统计学意义(P均<0.05)。结论 乳腺动态增强MRI的TIC曲线结合ADC值可在一定程度上预测IDC的组织学分级。 |
| 英文摘要: |
| Objective To explore the correlation of time-signal intensity curve (TIC) and ADC values with histopathologic classification in patients with invasive ductal carcinoma (IDC) of the breast. Methods Forty-three patients with IDC (45 lesions) confirmed by histopathology were retrospectively analyzed. All of them underwent dynamic enhancement MRI and DWI, and then the ADC values and the early enhancement rate of tumors were measured and the TIC were obtained. The difference of ADC values, early enhancement rate and TIC types among different pathological grading of IDC were compared, and their relationship with the pathological grading were analyzed. Results In 43 cases of IDC, 8 cases of grade Ⅰ, 24 cases of grade Ⅱ, and 11 cases of grade Ⅲ. Compared between any two gradings of IDC, there was no significant difference for the early enhancement rate (both P>0.05), while there was significant difference for the ADC values and TIC types (all P<0.05). There was negative correlation between histopathologic grading and ADC value (r=-0.79,P<0.01), and there was positive correlation between histopathologic grading and TIC types (r=0.40, P<0.01). The differences of ADC value between normal breast tissue and IDC with different grading were significant (all P<0.05). Conclusion The TIC curve of dynamic enhancement MRI combine with ADC value can be used to forecast pathological grading of IDC. |
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