| 张禹,张茜,朱友志,郝文胜,芦东徽,周俊平.原发性中枢神经系统淋巴瘤ADC值与预后的相关性[J].中国医学影像技术,2015,31(5):711~715 |
| 原发性中枢神经系统淋巴瘤ADC值与预后的相关性 |
| Correlation between prognosis and ADC value on primary central nervous system lymphoma |
| 投稿时间：2014-09-15 修订日期：2015-03-23 |
| DOI：10.13929/j.1003-3289.2015.05.018 |
| 中文关键词: 中枢神经系统 淋巴瘤 磁共振成像 无进展生存期 |
| 英文关键词:Central nervous system Lymphoma Magnetic resonance imaging Progression-free survival |
| 基金项目: |
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| 摘要点击次数: 2085 |
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| 中文摘要: |
| 目的 探讨原发性中枢神经系统淋巴瘤(PCNSL)患者DWI的ADC值与无进展生存期(PFS)、Ki-67标记指数之间相关性。方法 分析经临床和病理证实的28例PCNSL的MRI和免疫组化结果。分别测量肿瘤的ADC值并记录最小ADC值(ADCmin)、平均ADC值(ADCmean)及最大ADC值(ADCmax),并进行统计学分析。结果 28例中15例单发,13例多发。PFS与ADCmin呈正相关(r=0.565,P=0.002),PFS与Ki-67呈负相关(r=-0.627,P<0.001)。PFS与ADCmean、ADCmax均无相关性(r=0.324、-0.056,P=0.093、0.776)。Ki-67与ADCmin呈负相关(r=-0.575,P=0.001),Ki-67与ADCmean和ADCmax间均无相关性(r=-0.273、-0.094,P=0.159、0.636)。强化灶单发与多发患者间Ki-67和PFS以及≥60岁和<60岁间PFS差异均无统计学意义(P均>0.05)。结论 DWI可在治疗前初步判断PCNSL的PFS。 |
| 英文摘要: |
| Objective To investigate the correlation between progression-free survival (PFS), labeling index of Ki-67 and ADC values in the primary central cerebral system lymphoma (PCNSL). Methods MRI features and the Ki-67 expression level of 28 PCNSL patients confirmed by clinics and pathology were analyzed retrospectively. Minimum ADC value (ADCmin), mean ADC value (ADCmean) and the maximum ADC value (ADCmax) were measured and statistically analyzed. Results Twenty-eight cases included 15 cases of single and 13 cases of multiple. There was positive correlation between PFS and ADCmin (r=0.565, P=0.002), negative correlation between PFS and Ki-67 (r=-0.627, P<0.001). And there was no correlation between the PFS and ADCmax, ADCmean (r=0.324, -0.056, P=0.093, 0.776). There was negative correlation between Ki-67 and ADCmin (r=-0.575, P=0.001), and there was no correlation between Ki-67 and ADCmean, ADCmax (r=-0.273,-0.094, P=0.159, 0.636). The level of Ki-67 and PFS showed no significant difference between the patients of single lesions and multiple lesions (P>0.05). PFS showed no significant difference between patients ≥60 years and <60 years old (all P>0.05). Conclusion ADC value may be a predictable factor on PFS of PCNSL patients. |
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