| 宁宁,张育苗,张雷,李彦彦,李欢,杨健.3.0T磁共振R2*值评价足月出生婴儿脑深部灰质核团年龄相关性铁沉积[J].中国医学影像技术,2015,31(5):706~710 |
| 3.0T磁共振R2*值评价足月出生婴儿脑深部灰质核团年龄相关性铁沉积 |
| Age-related iron deposition of the full-term infants' deep gray nuclei detected by R2* values on 3.0T MR |
| 投稿时间：2015-01-05 修订日期：2015-03-11 |
| DOI：10.13929/j.1003-3289.2015.05.017 |
| 中文关键词: 婴儿 年龄 灰质 铁 磁共振成像 横向弛豫率 |
| 英文关键词:Infant Age Gray matter Iron Magnetic resonance imaging Transverse relaxation rate |
| 基金项目:国家自然科学基金面上项目(81471631、81171317)、教育部新世纪优秀人才计划(NCET-11-0438)、国家卫计委临床重点专科基金。 |
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| 中文摘要: |
| 目的 采用3.0T MR R2*值观察婴儿脑深部灰质核团铁沉积与周龄的关系。方法 纳入婴儿53名,校正周龄(PMA)37~92周。采用GE 3.0T磁共振扫描仪进行增强T2*加权血管成像(ESWAN)序列扫描,测量脑内双侧深部灰质核团(尾状核、壳核、苍白球、丘脑、红核和黑质)的R2*值。对各部位R2*值与脑铁含量进行相关分析,并分析R2*值与PMA的关系。结果 婴儿期脑深部灰质核团R2*值与脑铁含量均呈正相关(P均<0.001)。尾状核、壳核、苍白球、丘脑、红核和黑质的R2*值与PMA均呈正相关(r=0.865、0.818、0.893、0.844、0.742和0.834,P均<0.001)。结论 婴儿期脑深部灰质核团的R2*值随周龄增大逐渐增加,其可反映局部脑铁沉积随周龄的增加。 |
| 英文摘要: |
| Objective To investigate age-related iron deposition of the infants' deep gray nuclei detected by R2* values on 3.0T MR. Methods Fifty-three infants whose postmenstrual age (PMA) ranged from 37 to 92 weeks were examined by enhanced T2 star weighted angiography (ESWAN) in 3.0T MR system. The R2* values were measured from the deep gray nuclei (caudate nucleus, putamen, globus pallidus, thalamus, red nucleus and substantia nigra). Correlation analysis were performed to explore the relation between the R2* values and iron concentrations, PMA. Results R2* values had a positive correlation with the iron concentrations in the deep gray nuclei (all P<0.001). The significantly positive correlations between the R2* values of caudate nucleus, putamen, globus pallidus, thalamus, rednucleus and nigra and PMA were found (r=0.865, 0.818, 0.893, 0.844, 0.742 and 0.834, respectively, all P<0.001). Conclusion R2* values increase by age in the deep gray nuclei, which may reflect the age-related iron deposition in infants. |
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