| 于楠,金晨望,李艳,马军超,辛晓敏,高俊刚,郭佑民.CT定量分析观察慢性阻塞性肺疾病患者的肺小血管改变[J].中国医学影像技术,2015,31(2):173~176 |
| CT定量分析观察慢性阻塞性肺疾病患者的肺小血管改变 |
| Pulmonary vascular alteration in chronic obstructive pulmonary disease patients based on quantitative CT analysis |
| 投稿时间：2014-09-19 修订日期：2014-12-12 |
| DOI：10.13929/j.1003-3289.2015.02.004 |
| 中文关键词: 肺疾病,慢性阻塞性 肺气肿 体层摄影术,X线计算机 |
| 英文关键词:Pulmonary disease, chronic obstructive Emphysema Tomography, X-ray computed |
| 基金项目:国家卫生和计划生育委员会公益性行业科研专项基金(201402013) |
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| 中文摘要: |
| 目的 探索CT定量分析手段对慢性阻塞性肺疾病(COPD)小血管变化的识别能力,分析COPD患者肺小血管变化的影响因素。方法 回顾性收集121例COPD患者,其中48例患者有2次扫描结果,间隔时间超过1年。肺气肿定量以－950 HU密度以下低衰减区体积占总肺体积的百分比(%LAA-950)表示,单位面积内肺小血管的数量反应肺小血管的改变。分析各级二维平面内血管数量与%LAA-950的相关性。结果 右肺上叶尖段路径第5级支气管与全肺%LAA-950呈明显负相关(r=-0.87,P<0.01)。对比48例COPD患者的2次扫描结果,发现吸烟者(P=0.02)较既往吸烟者(P=0.07)单位面积内血管数量减少更明显。结论 CT定量分析COPD患者肺小血管数量的改变,具有直观、可量化的优点。COPD患者肺小血管的改变受吸烟状态和肺气肿的影响。 |
| 英文摘要: |
| Objective To evaluate the ability of the quantitative CT analysis in pulmonary vascular alteration, and the association of small pulmonary vessels with the extent of emphysema in chronic obstructive pulmonary disease (COPD). Methods A quantitative CT measurement was used to assess of both pulmonary vessels in 121 COPD patients, and its longitudinal changes over 2 years in 48 patients. The extent of emphysema was defined as percentage of low attenuation areas less than a threshold of-950 HU in whole lung (%LAA-950) on CT scan; the changes of small pulmonary vessels was evaluated with the number of small pulmonary vessels per unit area. The correlation between number of pulmonary vessels and %LAA-950 was analyzed. Results The total number of small pulmonary vessels in the level of the fifth generation of bronchus of right upper lobe section had the significant negative correlations with %LAA-950 (r=－0.87, P<0.01). The number of small pulmonary vessels per unit area was less in current smokers (P=0.02) than in former smokers (P=0.07). Conclusion CT can quantitatively analyze pulmonary vascular changes in COPD patients, which is intuitive and quantifiable. Changes of small pulmonary vessels in COPD patients can be affected by smoking status and emphysema quantification. |
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