| 刘彦英,陈青,赵晓虹,吴丽桑,许少兰,丛淑珍.孤立性鼻骨发育异常预测21-三体胎儿[J].中国医学影像技术,2015,31(1):95~97 |
| 孤立性鼻骨发育异常预测21-三体胎儿 |
| Isolated abnormal fetal nasal bone for fetus with 21-trisomy |
| 投稿时间：2014-07-28 修订日期：2014-12-03 |
| DOI：10.13929/j.1003-3289.2015.01.026 |
| 中文关键词: 胎儿 染色体 鼻骨 超声检查,产前 |
| 英文关键词:Fetus Chromosomes Nasal bone Ultrasonography, prenatal |
| 基金项目:广东省医学科研基金(A2014050)。 |
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| 中文摘要: |
| 目的 评估孤立性鼻骨发育异常预测21-三体胎儿的价值。方法 回顾性分析产前诊断发现的32胎鼻骨发育异常胎儿,孕11~32周。将32胎鼻骨异常胎儿分为两组,孤立性鼻骨发育异常组(21胎)和非孤立性鼻骨发育异常组(即同时合并其他系统异常,11胎)。采用Fisher确切概率法比较两组间21-三体的发生率。结果 孤立性鼻骨发育异常组21胎染色体结果均正常;非孤立性鼻骨发育异常组11胎中6胎染色体正常,5胎21-三体胎儿,二者21-三体胎儿发生率的差异有统计学意义(P=0.002)。结论 鼻骨发育异常、且同时合并其他系统异常的胎儿为21-三体的风险较高;而孤立性鼻骨发育异常胎儿染色体异常的风险较小。 |
| 英文摘要: |
| Objective To evaluate the diagnostic value of isolated abnormal fetal nasal bone for fetus with 21-trisomy. Methods Totally 32 fetuses (gestational age from 11 weeks to 32 weeks) with abnormal nasal bone were analyzed retrospectively. All fetuses were categorized into isolated dysplasia nasal bone group (n=21) and non-isolated dysplasia group (with other systems abnormity, n=11). The difference of incidence of 21-trisomy between two groups were compared by Fisher probabilities. Results All the 21 fetuses with isolated dysplasia nasal bone had normal karyotype. Among 11 fetuses in non-isolated dysplasia group, five fetuses with Down syndrome and six fetuses had normal karyotype. The difference of incidence of 21-trisomy between two groups were statistical significance (P=0.002). Conclusion Fetuses with abnormal nasal nose and other systems abnormality have higher risk of 21-trisomy, comparing with fetuses of solitary bone dysplasia. |
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