| 孟颖,梁宇霆,刘明明,张艺.原发性胆汁性肝硬化的MRI表现[J].中国医学影像技术,2014,30(12):1874~1878 |
| 原发性胆汁性肝硬化的MRI表现 |
| MRI findings of primary biliary cirrhosis |
| 投稿时间：2014-07-11 修订日期：2014-10-24 |
| DOI： |
| 中文关键词: 肝硬化,胆汁性 磁共振成像 晕征 淋巴结 |
| 英文关键词:Liver cirrhosis, biliary Magnetic resonance imaging Halo sign Lymph nodes |
| 基金项目: |
|
| 摘要点击次数: 2521 |
| 全文下载次数: 914 |
| 中文摘要: |
| 目的 总结原发性胆汁性肝硬化(PBC)的MRI征象,探讨MRI对PBC的诊断价值及其对肝纤维化程度的评估价值。方法 回顾性分析临床确诊为PBC的45例患者(其中33例接受肝穿刺活检)的MRI征象,并与病理结果进行相关性分析。结果 45例PBC的MRI征象:弥漫性肝大17例(17/45,37.78%);门静脉周围T2WI高信号影35例(35/45,77.78%);T2WI肝脏信号不均匀34例(34/45,75.56%);门静脉周围晕征34例(34/45,75.56%);腹部淋巴结增大39例(39/45,86.67%)。接受肝穿刺活检的33例PBC中,肝脏信号不均匀性分级与组织学分期存在明显正相关(r=0.703,P<0.001);晕征在组织学各期出现频率差异有统计学意义(P=0.034),晕征分级与组织学分期呈正相关(r=0.687,P<0.001),其中Ⅰ期与Ⅱ期比较,晕征分级无统计学意义(P=0.841),Ⅱ期与Ⅲ期、Ⅲ期和Ⅳ期比较差异有统计学意义(P均<0.05);增大淋巴结在组织学各期出现频率、大小差异均无统计学意义(P均>0.05)。结论 MRI诊断PBC有重要价值,晕征及肝脏信号不均匀性有助于肝纤维化程度的评估。 |
| 英文摘要: |
| Objective To evaluate MRI findings in patients with primary biliary cirrhosis (PBC) and to determine the value of MRI in diagnosis of PBC and assessment of liver fibrosis. Methods MRI findings of 45 PBC patients, including 33 patients who underwent liver biopsy and correlation between the MRI findings and the pathological stage were analyzed. Results Diffuse hepatomegaly and periportal hyperintensity were observed in 17 (17/45, 37.78%) and 35 patients (35/45, 77.78%), respectively; non-homogeneous changes of the liver signal intensity in 34 (34/45, 75.56%) and periportal halo sign in 34 patients (34/45, 75.56%); lymphadenopathy was in 39 (39/45, 86.67%) patients. Among 33 cases undergoing liver biopsy, a positive correlation was observed between histological stage and the non-homogeneity of liver signal intensity (r=0.703, P<0.001); There were significant difference among the four histological stages based on the periportal halo sign (P=0.034), and the grading of the periportal halo sign was found to be significantly correlated with the histological stages (r=0.687, P<0.001). Grading of the periportal halo sign was significantly different between stage Ⅱ and Ⅲ, stage Ⅲ and Ⅳ, no significant difference was found between stages Ⅰ and Ⅱ (P=0.841). There were no significant difference among the four histological stages in occurrence and size of enlarged lymph nodes, (all P>0.05). Conclusion MRI is valuable in the diagnosis of PBC, and periportal halo sign and liver signal intensity help to evaluate the degree of liver fibrosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
