| 韩露,张伟,王慧颖,戴文静,刘丹青,郭启勇.乳腺导管原位癌的X线影像特征及病理核分级与人表皮生长因子受体2、雌激素受体及孕激素受体表达的相关性[J].中国医学影像技术,2014,30(12):1857~1860 |
| 乳腺导管原位癌的X线影像特征及病理核分级与人表皮生长因子受体2、雌激素受体及孕激素受体表达的相关性 |
| Correlation between mammographic features, pathologic grade and human epidermal growth factor receptor 2, estrogen receptor, progesterone receptor expression of ductal carcinoma in situ |
| 投稿时间：2014-07-01 修订日期：2014-10-16 |
| DOI： |
| 中文关键词: 乳房X线摄影术 癌,导管内,非浸润性 雌激素受体 孕激素受体 人表皮生长因子受体2 |
| 英文关键词:Mammography Carcinoma, intraductal, noninfiltrating Estrogen receptor Progesterone receptor Human epidermal growth factor receptor 2 |
| 基金项目: |
|
| 摘要点击次数: 2115 |
| 全文下载次数: 1013 |
| 中文摘要: |
| 目的 探讨乳腺导管原位癌(DCIS)的X线影像特征及病理核分级与雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子受体2(HER2)表达的相关性。方法 回顾经手术病理证实为DCIS的患者105例,共107个病灶,术前均接受乳腺X线摄影检查,系统描述病变的X线影像学特征。分析不同病理核分级及其影像特征与不同肿瘤因子表达(HER2阳性组、ER阳性组和三阴组)的相关性。结果 钙化为DCIS的主要影像学特征(74/107,69.15%),HER2阳性组、ER阳性组、三阴组间钙化形态及分布类型的差异均有统计学意义(P均<0.05),HER2阳性组以区段样分布(23/45,51.11%),线状分枝状钙化(18/45,40.00%)表现为主,主要为高级别DCIS(38/55,69.09%)。ER阳性组以区域性分布(23/45,51.11%)、多形性钙化(12/23,52.17%)表现为主,以非高级别为主(22/42,52.38%)。结论 DCIS患者的乳腺X线表现特征与肿瘤的一些分子生物学表达存在相关性,可以间接反映肿瘤的某些生物学行为。 |
| 英文摘要: |
| Objective To explore the mammographic features and pathology classification of ductal carcinoma in suit (DCIS), and analyze the relationship between them and the expression of estrogen receptor (ER), progesterone receptor, (PR) and human epidermal growth factor receptor 2 (HER2). Methods One hundred and five patients with DCIS confirmed by pathology, a total of 107 lesions, were analyzed retrospectively. All patients underwent mammography examination before operation, and the mammography characteristics of the lesions were described systematically. The correlation between different pathological grade, imaging characteristics and different expression of the main immunohistochemical biomark (HER2 positive group, ER positive group and triple negative group) were analyzed. Results The calcification was the main image feature of DCIS (74/107, 69.15%). Among the HER2 positive group, ER positive group and triple negative group, there were significant differences between the morphology and distribution of calcification (both P<0.05). In HER2-positive group, fine linear branching (18/45, 40.00%) and segmental distribution calcifications (23/45, 51.11%) were the main features, and the lesions was more likely to be high grade (38/55, 69.09%). Amorphous (12/23, 52.17%) and regional distribution (23/45, 51.11%) calcifications were more frequently observed in ER positive group, and the lesions was more likely to be non-high grade (22/42, 52.38%). Conclusion There was a correlation between the mammographic features and the expression of some biological molecular biomark of DCIS. Mammographic features can indirectly reflect some biological behavior of the tumor. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
