| 赵小琪,刘慧,向红.卵巢癌超声造影与血管生成拟态和MVD的相关性分析[J].中国医学影像技术,2014,30(12):1792~1796 |
| 卵巢癌超声造影与血管生成拟态和MVD的相关性分析 |
| Correlation between vascular mimicry, microvessel density and contrast-enhanced of ovarian ultrasound cancer |
| 投稿时间：2014-08-05 修订日期：2014-10-14 |
| DOI： |
| 中文关键词: 卵巢肿瘤 超声检查 血管生成拟态 微血管密度 |
| 英文关键词:Ovarian neoplasms Ultrasonography Vascular mimicry Microvessel density |
| 基金项目:新疆医科大学第一附属医院科研奖励基金(2012YFY26)。 |
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| 中文摘要: |
| 目的 分析不同时期裸鼠卵巢癌移植瘤血管生成拟态(VM)密度、微血管密度(MVD)及其CEUS参数的相关性。方法 分别建立生长21天组、28天组裸鼠移植瘤模型,每组10只,对两组移植瘤模型行CEUS检查,分析各组时间强度曲线(TIC)及相关参数。应用CD31及PAS双重染色检测卵巢癌中VM表达及MVD。对两个时期移植瘤造影的峰值强度(PI)与相应的VM密度及MVD进行相关性分析。结果 成功制备移植瘤模型。CEUS显示,21天组、28天组的峰值强度(PI)、达峰时间(TTP)、持续时间(TTD)差异有统计学意义(P<0.05)。染色检测显示,21天组、28天组VM密度、MVD差异均有统计学意义(P均<0.05)。21天组PI与VM密度、MVD均呈正相关(r=0.657、0.652,P均<0.05);28天组PI与VM密度无相关性(P>0.05),PI与MVD呈正相关(r=0.687,P=0.03)。结论 不同时期卵巢癌CEUS与VM密度或MVD密切相关,对卵巢癌早期诊断有一定价值。 |
| 英文摘要: |
| Objective To analyze the correlation between CEUS ultrasound parameters, density of vascular mimicry (VM) and microvessel density (MVD) of different stages of ovarian cancer. Methods Twenty xenograft tumor models of ovarian cancer with SKOV3 cell lines were established, and divided into 21 days group and 28 days group according to survival time (10 mices in each group). CEUS was performed on corresponding time and the parameters including peak intensity (PI), time to peak (TTP), time to duration (TTD) were analyzed. MVD and the expression of VM were examined by CD31-PAS double stain. The correlation between PI and VM, MVD were analyzed in the two groups. Results Twenty xenograft tumor models was established effectively. There were statistically significant between the two groups in PI, TTP, TTD, MVD and the density of VM (all P<0.05). There were positive correlations between PI and the density of VM (r=0.657, P<0.05), PI and the MVD (r=0.652, P<0.05) in 21 days group. There was no correlation between PI and the density of VM in 28 days group (P>0.05). There was positive correlation between PI and MVD in 28 days group (r=0.687, P<0.05)). Conclusion CEUS ultrasound is closely related to the density of VM or MVD at different stages of ovarian cancer. CEUS has early diagnosisc value in ovarian cancer. |
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