| 陈向辉,Seunghan Ha,崔凯,查道刚,宾建平,李自成,刘伊丽.长脉冲超声条件下脂质体微泡协同rt-PA溶解微血栓[J].中国医学影像技术,2014,30(12):1769~1772 |
| 长脉冲超声条件下脂质体微泡协同rt-PA溶解微血栓 |
| Lipid microbubble synergistic rt-PA thrombolysis under long-pulsed ultrasound enhanced condition |
| 投稿时间：2014-07-08 修订日期：2014-10-11 |
| DOI： |
| 中文关键词: 超声检查 微泡 纤溶酶原激活剂 溶栓治疗 |
| 英文关键词:Ultrasonography Microbubbles Tissue plasminogen activator Thrombolytic therapy |
| 基金项目:广东省自然科学基金(S2013040015434)、高等学校博士学科点专项科研基金(20134401120005)、暨南大学第一临床医学院科研培育专项基金(2013202)。 |
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| 中文摘要: |
| 目的 观察长脉冲超声(US)条件下脂质体微泡造影剂协同重组组织型纤溶酶原激活剂(rt-PA)溶解微血栓的疗效。方法 采集6名健康受试者全血制备200~300 μm的微血栓,根据不同干预方式分为单纯rt-PA组、rt-PA+低占空比US组(5000个循环)、rt-PA+高占空比US 组(600 000个循环),另将仅US(600 000个循环)照射但无声学微泡协同作为单纯US组。根据辐照系统内压力减低程度评价溶栓的疗效。结果 单纯rt-PA组溶栓率与rt-PA+低占空比US组比较,差异无统计学意义(P>0.05),rt-PA+高占空比US组溶栓率高于单纯rt-PA组和rt-PA+低占空比US组(P均<0.01)。结论 长脉冲US声学微泡辅助rt-PA溶栓效果良好,但此协同作用需在低声压条件下依赖一定比例的占空比才能实现。 |
| 英文摘要: |
| Objective To observe the synergistic effect of lipid microbubble synergistic recombinant tissue plasminogen activator (rt-PA) thrombolysis under long-pulsed ultrasound (US) enhanced condition. Methods The whole blood of six healthy subjects were collected and 200—300 μm thrombi was prepared. All blood samples were divided into rt-PA group, rt-PA+low duty cycle group (5000 cycle), rt-PA+high duty cycle group (600 000 cycle) according to different intervene methods, meanwhile ultrasound irradiate without lipid microbubble as US group. Intra-system pressure was monitored to evaluate of the efficacy of thrombolysis. Results There was no significantly differences in thrombolytic rate between rt-PA+low duty cycle group and rt-PA group (P>0.05). The thrombolytic rate in rt-PA+high duty cycle group was higher than that of rt-PA group and rt-PA+low duty cycle group (both P<0.01). Conclusion rt-PA thrombolys assisted with long-pulsed US acoustic microbubbles is good, which is dependent on duty-cycle under low acoustic pressure condition. |
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