| 陈卫国,文婵娟,徐维敏,赵亮,周大菊,叶华秀,廖昕.乳腺导管内癌及乳腺导管内癌伴微小浸润癌临床、X线与病理表现对照[J].中国医学影像技术,2014,30(10):1509~1513 |
| 乳腺导管内癌及乳腺导管内癌伴微小浸润癌临床、X线与病理表现对照 |
| Comparison of clinical, X-ray and pathology findings of breast ductal carcinoma in situ and breast ductal carcinoma in situ with mirco-invasion |
| 投稿时间：2014-04-08 修订日期：2014-05-22 |
| DOI： |
| 中文关键词: 癌, 导管, 乳腺 乳房X线摄影术 病理学 |
| 英文关键词:Carcinoma, ductal, breast Mammography Pathology |
| 基金项目:广东省产学研结合重点项目课题（2011A090200056）、广东省科技计划项目（2012A032200011）。 |
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| 中文摘要: |
| 目的 探讨乳腺导管内癌（DCIS）及乳腺导管内癌伴微小浸润癌（DCIS-MI）的临床、X线及病理表现差异。方法 回顾性分析133例经手术病理证实的DCIS及DCIS-MI患者的临床、X线及病理学资料，其中DCIS组93例（96侧），DCIS-MI组40例（40侧）。结果 DCIS组49侧（49/96，51.04%）、DCIS-MI组10侧（10/40，25.00%）触诊阴性，差异有统计学意义（P<0.05）。DCIS组淋巴结转移均为阴性，DCIS-MI组4侧（4/40，10.00%）前哨淋巴结转移，7侧（7/40，17.50%）腋淋巴结转移，差异有统计学意义（P均<0.05）。两组X线主要征象差异有统计学意义（P<0.001），其中DCIS组单纯钙化比例较高（41/96，42.71%），DCIS-MI组钙化伴局灶性不对称/肿块比例较高（24/40，60.00%）；两组钙化形态及分布差异有统计学意义（P均<0.05），DCIS组钙化形态主要呈细小多形性（39/57，68.42%），成簇（25/57，43.86%）及段样（31/57，54.39%）分布，DCIS-MI组钙化形态多呈线样分支状（14/27，51.85%），段样（18/27，66.67%）分布。两组病灶最大径、组织学分级、分子亚型及Ki-67指数差异有统计学意义（P均<0.05）。结论 DCIS与DCIS-MI临床表现、X线征象及病理学特征具有一定差异，DCIS-MI更具浸润性癌特征。 |
| 英文摘要: |
| Objective To investigate the differences of clinical, X-ray and pathological findings between ductal carcinoma in situ (DCIS) and ductal carcinoma in situ with micro-invasive (DCIS-MI). Methods Clinical, X-ray and pathological data of 93 patients of DCIS (96 lateral breasts) and 40 patients of DCIS-MI (40 lateral breasts) were retrospectively analyzed. Results There were 49 (49/96, 51.04%) DCIS and 10 (10/40, 25.00%) DCIS-MI with negative sign (P<0.05). No metastasis of lymph nodes occurred in DCIS, and 4 (4/40, 10.00%) DCIS-MI had sentinel lymph node meatastasis, 7 (7/40, 17.50%) DCIS-MI had axillary lymph node meatastasis (P<0.05). There were significant differences of primary findings between DCIS and DCIS-MI (P<0.05), that was more lesions appeared as pure calcification in DCIS (41/96, 42.71%), while as micro-calcification complicated with focal asymmetry/mass in DCIS-MI (24/40, 60.00%). The morphology and distribution of calcification were different between DCIS and DCIS-MI (both P<0.05), that was calcification was mostly fine pleomorphic calcifications (39/57, 68.42%) with clustering (25/57, 43.86%) or segment (31/57, 54.39%) distribution in DCIS, and mostly linear or linear branching calcifications (14/27, 51.85%) with segment distribution (18/27, 66.67%) in DCIS-MI. There were significant differences of lesion's maximum diameter, histological grade, molecular subtype and Ki-67 index (all P<0.05). Conclusion There are differences of clinical, X-ray and pathological findings between DCIS and DCIS-MI, and the features of DCIS are more inclined to infiltrating cancer. |
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