| 饶良俊,杨智云,陈志丰,王晓燕,洪桂洵,唐刚华,初建平,张祥松.比较18F-FDG PET/CT、11C-MET PET/CT和MRI诊断神经胶质瘤能力的效能[J].中国医学影像技术,2014,30(10):1463~1466 |
| 比较18F-FDG PET/CT、11C-MET PET/CT和MRI诊断神经胶质瘤能力的效能 |
| Comparison of 18F-FDG PET/CT, 11C-MET PET/CT and MRI in diagnosis of glioma |
| 投稿时间：2014-08-19 修订日期：2014-09-20 |
| DOI： |
| 中文关键词: 神经胶质瘤 F18 氟脱氧葡萄糖 C11甲基蛋氨酸 体层摄影术, 发射型计算机 磁共振成像 |
| 英文关键词:Glioma Fluorodeoxyglucose F18 Methylmethionine C11 Tomography, emission-computed Magnetic resonance imaging |
| 基金项目:广东省科技计划项目（2012B031800381）。 |
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| 中文摘要: |
| 目的 比较18F-FDG PET/CT、11C-MET PET/CT及MRI诊断神经胶质瘤能力的差异。方法 对60例临床疑似神经胶质瘤患者行18F-FDG PET/CT、11C-MET PET/CT和MR检查，经手术或活检获得病理诊断。以病理学结果为金标准计算18F-FDG PET/CT、11C-MET PET/CT及MRI诊断神经胶质瘤的敏感度、特异度和准确率，比较三者间差异。结果 本组60例中，36例经病理证实为胶质瘤。18F-FDG PET/CT、11C-MET PET/CT和MRI的诊断灵敏度、特异度、准确率分别50.00%（18/36）、75.00%（18/24）、60.00%（36/60），97.22%（35/36）、91.67%（22/24）、95.00%（57/60）和63.89%（23/36）、79.17%（19/24）、70.00%（42/60）。11C-MET PET/CT诊断灵敏度和准确率均高于18F-FDG PET/CT和MRI（P均<0.05）；11C-MET PET/CT诊断低级别胶质瘤（I级和Ⅱ级）的灵敏度[94.12%（16/17）] 明显高于18F-FDG PET/CT[5.88%（1/17）；P<0.5] 。结论 11C-MET PET/CT显像诊断神经胶质瘤的能力高于MRI及18F-FDG PET/CT显像。 |
| 英文摘要: |
| Objective To compare the ability of 18F-FDG PET/CT, 11C-MET PET/CT and MRI for diagnosing glioma. Methods Sixty patients with suspected glioma were enrolled and underwent 18F-FDG PET/CT, 11C-MET PET/CT and MR scanning. Pathological diagnosis were obtained in all cases postoperatively or through biopsy. Taking pathology results as gold standards, the sensitivity, specificity and accuracy rate of 18F-FDG PET/CT, 11C-MET PET/CT and MRI in diagnosing glioma were calculated and compared. Results Among 60 cases, glioma was verified in 36 patients. The sensitivity, specificity and accuracy rate of diagnosing glioma was 50.00% (18/36), 75.00% (18/24) and 60.00% (36/60) in 18F-FDG PET/CT, 97.22% (35/36), 91.67% (22/24) and 95.00% (57/60) in 11C-MET PET/CT, 63.89% (23/36), 79.17% (19/24) and 70.00% (42/60) in MRI, significant differences of sensitivity and accuracy rate was found between 11C-MET PET/CT and 18F-FDG PET/CT as well as MRI (all P<0.05). The sensitivity of 11C-MET PET/CT in diagnosing low-grade (grade I and grade Ⅱ) glioma was significantly higher than that of 18F-FDG PET/CT (94.12%[16/17] vs 5.88%[1/17], P<0.05). Conclusion Compared with MRI and 18F-FDG PET/CT, 11C-MET PET/CT demonstrated higher diagnostic ability in diagnosing glioma. |
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