| 田墨涵,于丽娟,秦誉,王大龙,王欣,李迎辞.18F-FDG PET/CT结直肠癌总病灶糖酵解与淋巴结转移及淋巴管生成的关系[J].中国医学影像技术,2014,30(9):1382~1386 |
| 18F-FDG PET/CT结直肠癌总病灶糖酵解与淋巴结转移及淋巴管生成的关系 |
| Correlation of total lesion glycolysis on 18F-FDG PET/CT images with lymphatic metastasis and lymphangiogenesis in colorectal carcinoma |
| 投稿时间：2014-02-09 修订日期：2014-04-03 |
| DOI： |
| 中文关键词: 结直肠肿瘤 体层摄影术,发射型计算机,单光子 总病灶糖酵解 血管内皮细胞生长因子受体-3 肿瘤转移 |
| 英文关键词:Colorectal neoplasms Tomography, emission-computed, single-photon Total lesion glycolysis Vascular endothelial growth factor C Neoplasm metastasis |
| 基金项目:黑龙江省卫生厅科研课题（2012-671）。 |
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| 中文摘要: |
| 目的 探索结直肠癌（CRC）PET/CT显像总病灶糖酵解（TLG）与其淋巴管密度（LVD）和血管内皮细胞生长因子-C（VEGF-C）的关系。方法 回顾分析36例病理证实的CRC患者（淋巴结转移组19例，无淋巴结转移组17例）的术前PET/CT资料，记录最大标准摄取值（SUVmax）和TLG。以免疫组化分析肿瘤和正常黏膜葡萄糖转运蛋白-1（GLUT-1）和VEGF-C的表达，D2-40标记淋巴管，记数LVD，分析其与SUVmax及TLG的关系。结果 CRC组织VEGF-C和GLUT-1阳性表达率显著高于正常黏膜（P均<0.01）。淋巴结转移组的SUVmax、TLG、LVD和VEGF-C显著高于无淋巴结转移组（SUVmax：t=3.602，P=0.001；TLG：t=3.421，P=0.002；LVD：t=3.051，P=0.004；VEGF-C：χ2=8.047，P=0.045）。SUVmax与TLG、TLG与LVD、TLG与GLUT-1的累积光密度（IOD）值存在直线相关关系（r=0.607、0.654、0.367，P均<0.05）。VEGF-C不同表达等级间TLG和LVD差异有统计学意义（F=5.922、35.579，P均<0.001）。GLUT-1与VEGF-C的表达水平呈等级相关（r=0.302，P单侧=0.028）。结论 结直肠癌病灶的TLG与LVD和VEGF-C存在正相关，TLG可在一定程度上反映肿瘤淋巴结转移和淋巴管生成状况。 |
| 英文摘要: |
| Objective To explore correlation of total lesion glycolysis (TLG) with lymphatic vessel density (LVD) and expression level of vascular endothelial growth factor-C (VEGF-C) in colorectal cancer (CRC). Methods Retrospective analysis of 36 patients with CRC (19 cases with lymphatic metastasis, 17 cases without lymphatic metastasis) proved by pathology and underwent PET/CT examination before surgical operation. The maximum standardized uptake value (SUVmax) and TLG were recorded. Immunohistochemistry was used to analyze the expression of VEGF-C of tumor tissue and the normal mucosal tissue. D2-40 was used to mark the lymphatic endothelial cells, LVD was recorded, and their correlation with SUVmax and TLG were analyzed. Results Positive expression of glucose transporter protein 1 (GLUT-1) and VEGF-C in tumor tissue were remarkably higher than those of normal mucosal tissue (all P<0.01). Statistically significant differences of SUVmax, TLG, LVD and VEGF-C were found between lymphatic metastatic and non-lymphatic metastatic patients (SUVmax: t=3.602, P=0.001; TLG: t=3.421, P=0.002; LVD: t=3.051, P=0.004; VEGF-C: χ2=8.047, P=0.045). In tumor tissue, there were linear correlation between SUVmax and TLG, TLG and LVD, TLG and integral optical density (IOD) of GLUT-1 (r=0.607, 0.654, 0.367, all P<0.05). TLG and LVD in different groups of VEGF-C were statistically significant (F=5.922, 35.579, all P<0.001). The expression level of GLUT-1 and VEGF-C were rankly correlated (r=0.302, P=0.028). Conclusion TLG is positive correlated with LVD and VEGF-C, indicating that TLG may reflect lymphangiogenesis and lymphatic metastasis in CRC in some degree. |
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