| 明韦迪,李晓光,邓灵波,梁继详,金征宇.射频消融与手术切除结直肠癌肝转移的Meta分析[J].中国医学影像技术,2014,30(9):1371~1376 |
| 射频消融与手术切除结直肠癌肝转移的Meta分析 |
| Radiofrequency ablation versus resection for colorectal cancer liver metastases：A Meta-analysis |
| 投稿时间：2014-03-17 修订日期：2014-06-24 |
| DOI： |
| 中文关键词: 结直肠肿瘤 肝 肿瘤转移 消融技术 肝切除术 Meta分析 |
| 英文关键词:Colorectal neoplasms Liver Neoplasm metastasis Ablation techniques Hepatectomy Meta-analysis |
| 基金项目: |
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| 摘要点击次数: 2684 |
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| 中文摘要: |
| 目的 比较射频消融（RFA）和外科肝切除术（HR）对结直肠癌肝转移的治疗效果。方法 系统检索收集了PubMed、Cochrane Library、EMBASE、中国知网、中国生物医学文献数据库等关于RFA和HR在结直肠癌肝转移的临床对照试验，按Cochrane系统评价方法进行了评价，采用Stata 12.0软件进行Meta分析。结果 最终纳入文献13篇，共2348例患者，其中 RFA 972例，HR1376例。Meta分析结果显示，RFA患者3年、5年生存率明显高于HR患者（OR：0.56，95%CI：0.38~0.83，P=0.004；OR：0.47，95%CI：0.29~0.76，P=0.002）；RFA患者手术后总复发率明显高于HR患者（OR：2.79，95%CI：1.25~6.21，P=0.012）。结论 HR较RFA治疗结直肠癌肝转移术后生存率高，可作为临床优先考虑的治疗方法。 |
| 英文摘要: |
| Objective To compare the therapeutic efficacies between radiofrequency ablation (RFA) and hepatic resection (HR) for colorectal liver metastasis. Methods Systematic literature search of clinical studies was carried out to compare RFA and HR for colorectal liver metastasis in Pubmed, Embase and the Cochrane Library Central databases. China Knowledge Resource Integrated Database, Chinese Biomedical Literature Database. The quality of the include studies was assessed according to the Cochrane systematic review method, and data analysis was conducted by using Stata 12.0 soft ware. Results 13 studies were finally included, with a total of 2348 patients, of whom 972 cases underwent RFA and 1376 cases were subjected to surgical resection. The results of Meta-analysis showed RFA was significantly superior to HR in 3-year overall survival (OS; OR: 0.56, 95%CI: 0.38—0.83, P=0.004) and 5-year OS (OR:0.47, 95%CI: 0.29—0.76, P=0.002). The overall recurrence rate in RFA was higher than that in HR group (OR:2.79, 95%CI: 1.25—6.21, P=0.012). Conclusion Compared with RFA, patients with colorectal cancer liver metastases treated by HR have higher overall survival, which is worth of optical consideration for clinical application. |
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