| 邵晓梁,邵小南,王小松,徐梅,王跃涛.18F-FDG PET/CT检测正常成人不同脑区代谢水平性别和年龄的差异[J].中国医学影像技术,2014,30(9):1339~1343 |
| 18F-FDG PET/CT检测正常成人不同脑区代谢水平性别和年龄的差异 |
| Age and gender related metabolism differences in different cerebral regions in healthy adults using 18F-FDG PET/CT |
| 投稿时间：2014-04-28 修订日期：2014-06-17 |
| DOI： |
| 中文关键词: 脑 体层摄影术,发射型计算机 代谢 性别因素 年龄因素 |
| 英文关键词:Brain Tomography, emission-computed Metabolism Sex factors Age factors |
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| 中文摘要: |
| 目的 采用18F-FDG PET/CT检测正常成人不同脑区域代谢水平性别和年龄的差异。方法 回顾分析769名健康成人的脑18F-FDG PET/CT图像，按年龄分为≤30岁、31~40岁组、41~50岁组、51~60岁组、61~70岁组及≥71岁组。采用Scenium软件将脑PET图像标准化，自动勾画左右各待测脑区，包括额叶、颞叶、顶叶、扣带回、中央区、枕叶、距状裂及周围皮质、基底核、内侧颞叶和小脑，获得平均标准化摄取值（SUVmean），比较不同性别和不同年龄各脑区代谢水平差异。结果 左右中央区、左右距状裂及周围皮质SUVmean男女性别间差异无统计学意义（P均>0.05），余脑区SUVmean女性均明显高于男性（P均<0.05）；男性和女性左侧代谢优势脑区包括额叶、顶叶、扣带回、中央区、距状裂及周围皮质和小脑，右侧代谢优势脑区包括颞叶、枕叶、内侧颞叶，男性基底核为右侧优势，女性左右两侧无明显差异；随着年龄增加，除小脑外，余各脑区SUVmean均不同程度下降，左侧半球下降更为显著。结论 健康成人各脑区代谢水平存在性别和年龄差异，随年龄增加，左右脑代谢呈非对称性减低。 |
| 英文摘要: |
| Objective To explore the age and gender related metabolism differences in different cerebral in healthy adults using 18F-FDG PET/CT. Methods Brain 18F-FDG PET/CT data of 769 healthy adults were retrospectively analyzed. The subjects were divided into ≤30 years old, 31-40 years old, 41-50 years old, 51-60 years old, 61-70 years oldand ≥71 years old group. The PET images of the brain was standarizated and the different regions of right and left including frontal lobe, temporal lobe, parietal lobe, cingulate gyrus, central area, occipital lobe, calcarine and surrounding cortex cerebellum, basal ganglia, medial temporal lobe and cerebellar were automatically outlined by Scenium software. The mean standardized uptake value (SUVmean) of each region were assessed and compared between males and females, as well as different age groups. Results No differences of SUVmean in bilateral central area, calcarine and surrounding cortex cerebellum (both P>0.05) and significant differences of SUVmean in the other regions (all P<0.05) were found between males and females. In both males and females, dominant regions on the left included frontal lobe, parietal lobe, cingulate gyrus, central area, calcarine and surrounding cortex cerebellum and cerebellum, dominant regions on the right included temporal lobe, occipital lobe and medial temporal lobe. The right basal ganglia was dominant in males while there was no different between right and left in females. SUVmean in all regions except for cerebellum decreased along with age, which was more obvious on the left. Conclusion There are age and gender related metabolism differences in different cerebral in healthy adults, and the metabolism shows asymmetrical reduction in right and left hemishere along with age. |
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