| 钟洋,全红,杨志勇.1H-MRS检测儿童及青少年创伤后应激障碍大脑前扣带回代谢物改变[J].中国医学影像技术,2014,30(9):1335~1338 |
| 1H-MRS检测儿童及青少年创伤后应激障碍大脑前扣带回代谢物改变 |
| 1H-MRS in detection of metabolites changes in anterior cingulate cortex of pediatric and adolescent patients with post traumatic stress disorder |
| 投稿时间：2014-04-13 修订日期：2014-05-25 |
| DOI： |
| 中文关键词: 应激障碍,创伤后 磁共振波谱学 前扣带回 |
| 英文关键词:Stress disorders, post-traumatic Magnetic resonance spectroscopy Anterior cingulate cortex |
| 基金项目:国家自然科学基金（10875092）、湖北省自然科学基金（2012FKB04449）。 |
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| 中文摘要: |
| 目的 探讨儿童及青少年创伤后应激障碍（PTSD）患者1H-MRS中大脑前扣带回区代谢物水平的变化。方法 纳入汶川地震幸存者57人，包括10例PTSD患者、23名PTSD康复者和24名健康者。对所有研究对象行1H-MRS检查，检测大脑前扣带回区N-乙酰天门冬氨酸（NAA）、肌酸（Cr）、胆碱（Cho）、肌醇（MI）和谷氨酸和谷氨酰胺复合物（Glx）水平，计算并比较NAA/Cr、Glx/Cr、Cho/Cr、MI/Cr的差异。结果 Glx/Cr：PTSD患者（1.16±0.15）、PTSD患者+PTSD康复者（1.31±0.07）均明显低于健康者（1.59±0.10），PTSD患者明显低于PTSD康复者+健康者（1.48±0.07），差异均有统计学意义（P均<0.05），PTSD康复者（1.37±0.08）与健康者和PTSD患者间差异均无统计学意义（P均>0.05）。NAA/Cr、Cho/Cr和MI/Cr差异均无统计学意义（P均>0.05）。结论 1H-MRS中儿童及青少年PTSD患者大脑前扣带回区Glx明显下降，其改变可能在PTSD病理生理机制中发挥重要作用。 |
| 英文摘要: |
| Objective To investigate the changes of metabolites level in anterior cingulate cortex of pediatric and adolescent patients with post traumatic stress disorder (PTSD) using 1H-MRS. Methods Totally 57 earthquake survivors including 10 PTSD patients, 23 rehabilitative subjects and 24 healthy subjects were enrolled. 1H-MRS of anterior cingulate cortex was performed in all the subjects. The level of N-acetylaspartate (NAA), Creatine (Cr), Choline (Cho), Glutamate-Glutamine (Glx) and Myo-Inositol (MI) was detected, and the NAA/Cr, Glx/Cr, Cho/Cr, MI/Cr was calculated and compared between different subjects. Results Glx/Cr in PTSD patients (1.16±0.15) and PTSD patients+rehabilitative subjects (1.31±0.07) were both significantly lower than those in healthy subjects (1.59±0.10, both P<0.05). Glx/Cr in PTSD patients was significantly lower than that in rehabilitative subjects+healthy subjects (1.48±0.07, P<0.05). There were no differences of Glx/Cr between rehabilitative subjects (1.37±0.08) and healthy subjects as well as PTSD patients (both P>0.05). No differences were found between the three kinds of subjects for NAA/Cr, Cho/Cr and MI/Cr (all P>0.05). Conclusion In 1H-MRS, the level of Glx in anterior cingulate cortex reduces significantly in pediatric and adolescent PTSD patients, which may play an important role in pathogenesis of PTSD. |
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