| 陈卫国,徐维敏,文婵娟,赵亮,周大菊,叶华秀,廖昕.乳腺导管内癌的X线表现与组织病理学、分子分型的对照研究[J].中国医学影像技术,2014,30(8):1211~1215 |
| 乳腺导管内癌的X线表现与组织病理学、分子分型的对照研究 |
| Control study of X-ray appearances and histopathology, molecule subtype of breast ductal carcinoma in situ |
| 投稿时间：2014-03-20 修订日期：2014-06-03 |
| DOI： |
| 中文关键词: 乳腺肿瘤 乳房X线摄影术 病理学 分子分型 |
| 英文关键词:Breast neoplasms Mammography Pathology Molecular type |
| 基金项目:广东省产学研结合重点项目课题（2011A090200056）、广东省科技计划项目（2012A032200011）。 |
|
| 摘要点击次数: 2880 |
| 全文下载次数: 1151 |
| 中文摘要: |
| 目的 探讨乳腺导管内癌（DCIS）的X线表现与组织级别、分子分型及Ki-67的关系。方法 回顾性分析133例136侧DCIS的X线表现及组织病理学、免疫组织化学结果。结果 ①136侧DCIS低级别19侧、中级别9侧、高级别108侧；低、中级别X线多表现为单纯钙化（10/28，35.71%），高级别为钙化伴局灶性不对称/肿块（38/108，35.19%）。②136侧DCIS中，Luminal A型70侧（70/136，51.47%）、Luminal B型17侧（17/136，12.50%）、Her-2过表达型41侧（41/136，30.15%）及三阴性型8侧（8/136，5.88%）；除Her-2过表达型多以钙化伴局灶性不对称/肿块（17/41，41.46%）为主要表现外，Luminal A型（23/70，32.86%）、Luminal B型（8/17，47.06%）及三阴性型（4/8，50.00%）均以单纯钙化多见，差异无统计学意义（χ2=17.408，P=0.135）。③ER/PR（+）钙化形态多为细小多形性（35/51，68.63%）、成簇分布（27/51，52.94%）；ER/PR（-）多为线样分支状（19/33，57.58%）、段样分布（23/33，69.70%）。Her-2过表达钙化形态多为线样分支状（20/38，52.63%）、段样分布（25/38，65.79%）；Her-2（-）多为细小多形性（33/46，71.74%）、成簇分布（24/46，52.17%），差异有统计学意义（P均<0.05）。④Ki-67≤10%时，钙化形态多为细小多形性（15/17，88.24%）；当Ki-67>30%时，钙化形态多为线样分支状（14/29，48.28%），差异有统计学意义（χ2=10.776，P=0.029）。结论 DCIS X线以钙化为主要表现，钙化的形态、分布在一定程度上可反映组织级别及ER/PR、Her-2、Ki-67的表达情况。 |
| 英文摘要: |
| Objective To explore the relationship of the X-ray appearances and histopathology, molecule subtype, proliferation index of the Ki-67 of the breast ductal carcinoma in situ (DCIS). Methods The X-ray appearances, histopathology and immunhistochemistry of the 133 cases DCIS (all 136 lateral-breast) were retrospectively analyzed. Results The 136 laterals DCIS included low-grade 19 laterals, intermediate-grade 9 laterals and high-grade 108 laterals. The main X-ray appearance of the low- and intermediate-grade DCIS were calcification (10/28, 35.71%), while the high-grade was calcification with focal dissymmetry/mass (38/108, 35.19%). ②All cases included the Luminal A 70 laterals (70/136, 51.47%), Luminal B 17 laterals (17/136, 12.50%), Her-2-overexpress 41 laterals (41/136, 30.15%) and triple-receptors negative 8 laterals (8/136, 5.88%). The main X-ray appearance of the Her-2-overexpress was calcification with focal dissymmetry/mass (17/41, 41.46%), the other molecule subtypes were purely calcifications. There was no statistical significance in the main X-ray appearance of different molecule subtypes (χ2=17.408, P=0.135). ③The ER/PR (+) cases of main appearance of the calcifications were fine pleomorphic (35/51, 68.63%), cluttered (27/51, 52.94%), while the ER/PR (-) cases were linear branching (19/33, 57.58%), segment (23/33, 69.70%); the Her-2 (+) cases were linear branching (20/38, 52.63%), segment (25/38, 65.79%), while the Her-2 (-) cases were fine pleomorphic (33/46, 71.74%), cluttered (24/46, 52.17%). There was statistical significance in the main appearance of the calcifications of them (all P<0.05). ④When the proliferation index of the Ki-67≤10%, the main morphous of the calcifications was fine pleomorphic (15/17, 88.24%), while the proliferation index of the Ki-67>30%, it was found linear branching (14/29, 48.28%; χ2=10.776, P=0.029). Conclusion The main X-ray appearance of the DCIS is calcifications. The morphous, distrutions of the calcifications may reflect the ER, PR, Her-2 and the proliferation index of the Ki-67. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
