| 李文婵,姚稚明,陈聪霞,刘甫庚,屈婉莹.18F-FDG PET综合指标鉴别诊断孤立性肺结节良恶性[J].中国医学影像技术,2014,30(7):1037~1040 |
| 18F-FDG PET综合指标鉴别诊断孤立性肺结节良恶性 |
| 18F-FDG PET in differential diagnosis of benign and malignant solitary pulmonary nodule with comprehensive criterion |
| 投稿时间：2013-09-30 修订日期：2014-05-22 |
| DOI： |
| 中文关键词: 肺肿瘤 孤立性肺结节 体层摄影术,发射型计算机 |
| 英文关键词:Lung neoplasms Solitary pulmonary nodule Tomography, emission-computed |
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| 中文摘要: |
| 目的 探讨18F-FDG PET中联合放射性摄取程度、形态及双时相显像标准摄取值（SUV）改变情况诊断孤立性肺结节（SPN）良恶性的效能。方法 回顾性分析64例经病理或临床随诊确诊的SPN患者18F-FDG PET/CT资料。根据SPN放射性摄取程度、形态及双时相显像SUV改变情况制定诊断标准，比较该标准与“2.5标准”（早期显像SUVmax≥2.5诊断为恶性）诊断恶性SPN的灵敏度、特异度、准确率、阳性预测值和阴性预测值。结果 按本组标准和“2.5标准”18F-FDG PET诊断恶性SPN的灵敏度、特异度、准确率、阳性预测值、阴性预测值分别为85.71%（42/49）、72.73%（8/11）、83.33%（50/60）、93.33%（42/45）、53.33%（8/15）和51.92%（27/52）、75.00%（9/12）、56.25%（36/64）、90.00%（27/30）、26.47%（9/34），灵敏度和准确率二者差异有统计学意义（P均<0.05）。结论 18F-FDG PET中，联合放射性摄取程度、形态及双时相显像SUV改变情况制定诊断标准可提高鉴别诊断SPN良恶性的准确率，具有一定临床应用价值。 |
| 英文摘要: |
| Objective To explore the ability of 18F-FDG PET in differential diagnosis of benign and malignant solitary pulmonary nodule (SPN) with comprehensive criterion based on the morphology and degree of 18F-FDG uptake and the change of standardized uptake value (SUV) in dual-phase imaging. Methods 18F-FDG PET/CT data of 64 patients with SPNs confirmed by pathology or follow-up were retrospectively analyzed. The diagnostic criterion of 18F-FDG PET in differential diagnosis of SPNs was designed based on the morphology and degree of 18F-FDG uptake and the change of SUV in dual-phase imaging. The sensitivity, specificity, accuracy, positive and negative predictive value of 18F-FDG PET/CT according to above diagnostic criterion and 2.5 criterion (SPN with SUVmax≥2.5 was diagnosed as malignant lesion) were calculated and compared. Results The sensitivity, specificity, accuracy, positive and negative predictive value of 18F-FDG PET/CT was 85.71% (42/49), 72.73% (8/11), 83.33% (50/60), 93.33% (42/45), 53.33% (8/15) according to the diagnostic criterion designed in this study, and 51.92% (27/52), 75.00% (9/12), 56.25% (36/64), 90.00% (27/30), 26.47% (9/34) according to 2.5 criterion. There were significant differences of sensitivity and accuracy between the two criterions (both P<0.05). Conclusion Using comprehensive criterion based on the morphology and degree of 18F-FDG uptake and the change of SUV in dual-phase imaging can improve the diagnostic accuracy of benign and malignant SPN, with certain clinical application value. |
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