| 周晓亮,邓豪余,李新辉,吴武林,娄明武,莫逸,谢爱民.18F-FDG PET/CT显像与血清VEGF水平诊断非小细胞肺癌[J].中国医学影像技术,2014,30(7):1028~1031 |
| 18F-FDG PET/CT显像与血清VEGF水平诊断非小细胞肺癌 |
| 18F-FDG PET/CT imaging and serum VEGF level in diagnosis of non-small cell lung cancer |
| 投稿时间：2014-02-18 修订日期：2014-04-26 |
| DOI： |
| 中文关键词: 癌,非小细胞肺 血管内皮生长因子 标准化摄取值 正电子发射型体层摄影术 |
| 英文关键词:Carcinoma, non-small-cell lung Vascular endothelial growth factor Standardized uptake value Positron-emission tomography |
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| 中文摘要: |
| 目的 观察血清VEGF水平与18F-FDG PET/CT显像对非小细胞肺癌（NSCLC）的诊断价值。方法 对40例NSCLC患者（NSCLC组，包括鳞癌19例、腺癌19例、肺泡癌2例）、20例肺部良性病变患者（良性组）行全身PET/CT显像检查和血清VEGF检测，同时检测20名健康体检者（健康对照组）的血清VEGF水平。分别比较3组及NSCLC组内鳞癌、腺癌患者血清VEGF水平，分析血清VEGF水平与肿块SUV的相关性，观察 PET/CT T分期、N分期和M分期NSCLC与血清VEGF水平的关系。结果 NSCLC组血清VEGF水平为（600.27±324.73）pg/ml，明显高于健康对照组[（176.75±109.85 pg/ml]和良性组[（290.55±144.90）pg/ml，P<0.05] 。NSCLC患者血清VEGF水平与肿块SUV呈正相关（r=0.609，P<0.01）。PET/CT T1期与T3期和T4期、T2期与T4期NSCLC、肿块SUV≥2.5和SUV<2.5、有无远处转移者之间血清VEGF水平差异均有统计学意义（P均<0.05）。结论 通过检测NSCLC患者血清VEGF水平，可在一定程度上预测临床分期，并提示预后。 |
| 英文摘要: |
| Objective To evaluate the serum vascular endothelial growth factor (VEGF) level and 18F-FDGPET/CT imaging in diagnosis of non-small cell lung cancer (NSCLC). Methods Forty patients with NSCLC (NSCLC group, including 19 squamous cell carcinoma, 19 adenocarcinoma and 2 bronchial alveolar carcinoma) and 20 with benign pulmonary diseases (benign group) underwent whole-body PET/CT imaging and detection of serum VEGF taken that in 20 healthy persons (control group) as standard. The serum VEGF levels in 3 groups were compared, as well as between lung squamous cell carcinomas and adenocarcinomas, among different T staging, N staging and M staging of tumors, and the correlation of serum VEGF with tumor SUV was analyzed. Results The serum VEGF level in NSCLC patients ([600.27±324.73]pg/ml) was significantly higher than that in control group ([176.75±109.85]pg/ml) and benign group ([290.55±144.90]pg/ml, all P<0.05). The serum VEGF level in NSCLC patients was associated with tumor's SUV (r=0.609, P<0.01). According to PET/CT findings, the serum VEGF levels were statistically different among tumors in T1 phase, T3 phase and T4 phase, T2 phase and T4 phase, as well as tumors with SUV≥2.5 and SUV<2.5, with or without distant metastasis (all P<0.05). Conclusion Detection of serum VEGF of NSCLC patients may help to predict clinical staging and prognosis in a certain extent. |
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