| 王湘彬,赵小虎,江虹,席芊,王培军.轻度认知功能障碍患者大脑fMRI网络小世界特性[J].中国医学影像技术,2014,30(5):790~793 |
| 轻度认知功能障碍患者大脑fMRI网络小世界特性 |
| Small-worldness of brain fMRI network in patients with mild cognitive impairment |
| 投稿时间：2013-11-26 修订日期：2014-03-26 |
| DOI： |
| 中文关键词: 轻度认知功能障碍 小世界特性 大脑功能网络 磁共振成像 |
| 英文关键词:Mild cognitive impairment Small-worldness Functional network Magnetic resonance imaging |
| 基金项目:国家自然科学基金项目（30970818、30770615、81271552、91071201）、上海市科委重点项目（11JC1412000、07JC14054）、上海市科委引导类项目（124119a5000）、上海市卫生系统重点项目（2013ZYJB0012）。 |
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| 中文摘要: |
| 目的 应用静息态fMRI观察轻度认知功能障碍（MCI）患者大脑功能网络是否具有小世界特性。方法 采集13例MCI患者（MCI组）和17名正常老年人（NC组）的大脑静息态BOLD-fMRI数据。采用SPM5软件对图像进行预处理，将大脑分割为90个区域，计算90个区域间的相关系数。以矩阵稀疏度（Sparsity）为阈值，将相关矩阵转换为网络。计算网络的聚类系数（C）和平均路径长度（L），若满足γ=C/Crand>1且λ=L/Lrand≈1（rand代表相应随机网络），为则认为大脑功能网络具有小世界特性。采用双样本t检验比较MCI组与NC组大脑功能网络小世界参数的差异。结果 在0.10~0.40阈值范围内，MCI组和NC组均符合γ>1且λ≈1。MCI组γ和δ均大于NC组，且在0.10≤Sparsity≤0.18时差异有统计学意义（P<0.05）；MCI组λ在各阈值处均小于NC组，在Sparsity=0.18、0.28和0.32处差异有统计学意义（P<0.05）。结论 MCI患者大脑fMRI网络具有小世界特性，且与正常老年人相比有所增强。 |
| 英文摘要: |
| Objective To observe whether the functional network in brain of mild cognitive impairment (MCI) patients have small-world property using resting-state BOLD-fMRI. Methods Totally 13 patients with MCI (MCI group) and 17 healthy elders (NC group) were involved. Resting-state BOLD-fMRI data were acquired and preprocessed with SPM 5 software. The whole brain was divided into 90 regions, and the correlation coefficient of each pair of those 90 regions was calculated. Taking the sparsity of matrix (Sparsity) as threshold, the correlation matrix was transferred to a network, and then the clustering coefficient (C) and shortest path length (L) were calculated. If γ=C/Crand>1 and λ=L/Lrand≈1 satisfied simultaneously (rand representing relative random networks), the network was considered to be a small-world network. Two samples t-test was adopted to test the differences of small-world parameters of brains' functional network between MCI group and NC group. Results γ>1 and λ≈1 were satisfied in both groups within the range of 0.10≤Sparsity≤0.40. γ and δ of MCI group were larger than those of NC group at each threshold, and the differences were significant at 0.10≤Sparsity≤0.18 (P<0.05). λ of MCI group was smaller than that of NC group at each threshold, and the differences were significant at Sparsity=0.18, 0.28 and 0.32 (P<0.05). Conclusion The brain's fMRI network of MCI patients have small-world property, which are enhanced compared with that of normal elders. |
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