| 李旭东,何暋易,王东宁,胡暋元,王文文,黄仁魏.18F-FDG PET/CT诊断继发性噬血细胞综合征原发病因[J].中国医学影像技术,2014,30(5):780~783 |
| 18F-FDG PET/CT诊断继发性噬血细胞综合征原发病因 |
| 18F-FDG PET/CT in diagnosing the primary disease of secondary hemophagocytic syndrome |
| 投稿时间：2013-12-27 修订日期：2014-03-12 |
| DOI： |
| 中文关键词: 淋巴组织细胞增多症，噬血细胞性 淋巴瘤 正电子发射型体层摄影术 氟脱氧葡萄糖F18 |
| 英文关键词:Lymphohistiocytosis, hemophagocytic Lymphoma Positron-emission tomography Fluorodeoxyglucose F18 |
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| 中文摘要: |
| 目的 探讨18F-FDGPET/CT诊断继发性噬血细胞综合征原发病因的价值。方法 回顾性分析19例继发性噬血细胞综合征患者的18F-FDGPET/CT资料，将诊断结果与临床诊断结果进行对比；采用18F-FDGPET/CT监测3例淋巴瘤相关噬血细胞综合征疾病进展。结果 13例18F-FDGPET/CT提示为恶性淋巴瘤，表现为多发淋巴结、脾脏或骨髓高代谢灶，其中9例确诊为非霍奇金淋巴瘤，4例诊断不明；6例18F-FDGPET/CT未提示恶性肿瘤，其中2例确诊为系统性红斑狼疮、1例确诊为EB病毒感染、1例确诊为溃疡性结肠炎、1例确诊为成人斯蒂尔病，1例病因不明。3例淋巴瘤相关噬血细胞综合征患者病情改善时18F-FDGPET/CT示原高代谢灶消失，疾病复发时出现新的高代谢病灶。结论 18F-FDGPET/CT对于早期诊断继发性噬血细胞综合征的病因、尤其是鉴别疾病良恶性具有重要价值，亦可监测原发病进展情况。 |
| 英文摘要: |
| Objective To explore the value of 18F-FDG PET/CT in diagnosing the primary disease of secondary hemophagocytic syndrome. Methods 18F-FDG PET/CT data of 19 patients with secondary hemophagocytic syndrome were retrospectively analyzed, and the outcomes were compared with clinical results. The situation of 3 cases with lymphoma-associatied hemophagocytic syndrome was monitored with 18F-FDG PET/CT. Results Malignant lymphoma was indicted in 13 patients by 18F-FDG PET/CT, which presenting as high metabolic lesions of lymph nodes, spleen and bone marrow, among them 9 were diagnosed as non-Hodgkin's lymphoma, 4 were not finally diagnosed. Nonmalignant lesions were found in 6 patients with 18F-FDG PET/CT, among them 2 were diagnosed as systemic lupus erythematosus, 1 as Epstein-Barr virus infection, 1 as ulcerative colitis, 1 as adult onset Still's disease, and 1 was not finally diagnosed. Three patients of lymphoma-associatied hemophagocytic syndrome were monitored by 18F-FDG PET/CT, present as disappearance of high metabolic lesions when clinical symptoms improved, but appearances of new high metabolic lesions when the disease relapsed. Conclusion 18F-FDG PET/CT is of great value in diagnosing primary disease of secondary hemophagocytic syndrome, especially in differentiating benign and malignant lesions. In addition, 18F-FDG PET/CT is useful for monitoring the progresses of primary disease. |
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