| 孙迪,申锷,魏聪,李艺,胡兵.声触诊组织量化技术评价肾脏恶性肿瘤弹性[J].中国医学影像技术,2014,30(4):591~594 |
| 声触诊组织量化技术评价肾脏恶性肿瘤弹性 |
| Virtual touch tissue quantification in evaluation on elasticity of renal malignant tumors |
| 投稿时间：2014-02-12 修订日期：2014-02-23 |
| DOI： |
| 中文关键词: 肾脏肿瘤 癌,肾细胞 声触诊组织量化 |
| 英文关键词:Kidney neoplasms Carcinoma, renal cell Virtual touch tissues quantification |
| 基金项目:国家自然科学基金（81271597、81270208）；上海市科委基金项目（04XD14013）；上海市市级医院新兴前沿技术联合攻关项目（SHDC12010104）。 |
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| 中文摘要: |
| 目的 采用声触诊组织量化（VTQ）技术观察肾脏恶性肿瘤的弹性特征，评价其对肾透明细胞癌（CCRCC）的鉴别诊断价值。方法 采用VTQ技术对54例患者的肾恶性肿瘤及周围正常肾皮质进行剪切波速度（SWV）检测，观察各类肾肿瘤的弹性表现及不同大小CCRCC的弹性特点，比较直径<3 cm的CCRCC与其他肿瘤的弹性差异，通过ROC曲线评价VTQ技术对<3 cm的CCRCC的鉴别诊断价值。结果 54例中，CCRCC 40例，嫌色细胞癌4例，乳头状肾细胞癌3例，肾盂尿路上皮癌7例；各类肿瘤SWV与肾皮质差异均无统计学意义（P均>0.05）；13例<3 cm的CCRCC的SWV高于肾皮质（P=0.01），且ΔSWV（SWV肿瘤-SWV皮质）显著高于其他类型肿瘤（P<0.01），以△SWV≥0为标准诊断<3 cm CCRCC的ROC曲线下面积为0.897，敏感度76.9%，特异度91.7%，准确率84.6%。结论 CCRCC、嫌色细胞癌、乳头状肾细胞癌和肾盂尿路上皮癌的弹性与肾皮质无显著差异，直径<3 cm的CCRCC较肾皮质韧，且硬度高于其他3种肿瘤；VTQ技术对<3 cm的CCRCC有中等鉴别诊断价值。 |
| 英文摘要: |
| Objective To explore the elasticity characteristics of renal malignant tumors with virtual touch tissue quantification (VTQ), and to evaluate its value on differential diagnosis of renal clear cell carcinoma (CCRCC). Methods VTQ was employed to detect the shear wave velocity (SWV) of 54 renal malignant tumors and the surrounding normal renal cortex, in order to observe the elasticity of different types of malignant renal tumors, especially CCRCC of different sizes. Then the elasticity was compared among different types of malignant renal tumors with diameter less than 3 cm, and ROC curve was used to evaluate the value of VTQ on differential diagnosis of CCRCC less than 3 cm. Results No difference of SWV among tumors and normal cortex was found in 54 renal malignant tumors (all P>0.05), including CCRCC (n=40), chromophobe cell carcinoma (n=4), papillary renal cell carcinoma (n=3) and urothelial carcinoma (n=7). SWV of CCRCCs smaller than 3 cm (n=13) was higher than that of surrounding cortex (P=0.01), and ΔSWV (SWV difference between the tumor and the cortex) of CCRCC was higher than that of other types (P<0.01). Taking △SWV≥0 as the cut-off value to diagnose CCRCC less than 3 cm, the area under the curve (AUC) was 0.897, the sensitivity, specificity and accuracy was 76.9%, 91.7% and 84.6%, respectively. Conclusion There is no significant difference of elasticity between CCRCC, chromophobe cell carcinoma, papillary renal cell carcinoma, urothelial carcinoma and the surrounding cortex. CCRCC with diameter less than 3 cm is stiffer than that of surrounding cortex and the other 3 types of renal tumors. VTQ imaging shows medium diagnostic value for CCRCC smaller than 3 cm. |
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