| 胡巧,康利克,王小燕,吴潮清,陈海宁,黄小莉.声触诊组织定量分析技术分期诊断慢性肾病[J].中国医学影像技术,2014,30(3):453~456 |
| 声触诊组织定量分析技术分期诊断慢性肾病 |
| Virtual touch tissue quantification in staging of chronic kidney disease |
| 投稿时间：2013-04-22 修订日期：2013-05-28 |
| DOI： |
| 中文关键词: 声脉冲辐射力成像 声触诊组织定量技术 慢性肾病 |
| 英文关键词:Acoustic radiation force impulse Virtual touch tissue quantification Nephrosis |
| 基金项目:广西自然科学基金青年基金项目（2012GXNSFBA053083）。 |
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| 中文摘要: |
| 目的 探讨声触诊组织定量（VTQ）技术分期诊断慢性肾病（CKD）的价值。方法 应用VTQ技术测量120例CKD患者双侧肾实质剪切波传播速度（SWV），构建ROC曲线，评价VTQ技术诊断CKD临床分期的价值。结果 不同临床分期CKD患者肾实质的SWV测值差异有统计学意义（P<0.001）；肾实质SWV测值与肾小球滤过率呈正相关（r=0.567，P<0.001），与CKD临床分期呈负相关（r=-0.616，P<0.001）；以2.52、2.46、2.24和2.21 m/s为界值诊断≥2期、≥3期、≥4期以及5期CKD的敏感度分别为84.4%、88.4%、84.9%和82.4%，特异度分别为70.0%、64.7%、68.7%和62.8%，ROC曲线下面积分别为0.834、0.829、0.832和0.775。结论 VTQ技术可无创定量评价CKD肾实质弹性变化，进而分期诊断慢性肾病，具有广阔临床应用前景。 |
| 英文摘要: |
| Objective To investigate the value of virtual touch tissue quantification (VTQ) in staging of chronic kidney disease (CKD). Methods VTQ was performed in 120 patients with CKD. Shear wave velocity (SWV) of renal parenchyma was measured in different stage groups. ROC curve analyses were performed to assess the value of VTQ in staging diagnosis of CKD. Results SWV of renal parenchyma had statistical differences among different stage groups (P<0.001). SWV was positively correlated with glomerular filtration rate (r=0.567, P<0.001) and negatively correlated with clinical stage (r =-0.616, P<0.001). ROC analyses indicated that the area under the curve was 0.834, 0.829, 0.832 and 0.775 for stages ≥2, ≥3, ≥4 and stage 5. The sensitivity and specificity of SWV in predicting CKD stages of ≥2, ≥3, ≥4 and stage 5 was 84.4%, 88.4%, 84.9%, 82.4% and 70.0%, 64.7%, 68.7%, 62.8% with cut-off point of 2.52, 2.46, 2.24 and 2.21 m/s, respectively. Conclusion VTQ can stage CKD through assessment of the renal elasticity noninvasively and quantitatively in patients with CKD, therefore having great clinical application prospect. |
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