| 高敏,邱传亚,周玉荣,蒋珊珊,蒋涛.氢质子磁共振波谱技术检测一氧化碳中毒迟发性脑病海马代谢产物[J].中国医学影像技术,2014,30(3):348~351 |
| 氢质子磁共振波谱技术检测一氧化碳中毒迟发性脑病海马代谢产物 |
| Magnetic resonance spectroscopy in assessing metabolism of hippocampus in patients with delayed encephalopathy after acute carbon monoxide poisoning |
| 投稿时间：2013-09-09 修订日期：2014-01-09 |
| DOI： |
| 中文关键词: 一氧化碳中毒 海马 磁共振波谱 |
| 英文关键词:Carbon monoxide poisoning Hippocampus Magnetic resonance spectroscopy |
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| 中文摘要: |
| 目的 采用1H-MRS评价一氧化碳中毒后迟发性脑病（DEACMP）患者海马代谢产物的变化。方法 纳入43例DEACMP患者（DEACMP组）和30名健康志愿者（对照组），两组研究对象按年龄分年轻亚组（<50岁）和年老亚组（≥50岁）。对所有研究对象进行双侧海马区1H-MRS扫描，采用单体素分辨自旋回波序列的点解析波谱法采集数据，检测双侧海马区N-乙酰天门冬氨酸/肌酸（NAA/Cr）、胆碱/肌酸（Cho/Cr）值，采用独立样本t检验比较组间数据差异。结果 对照组与DEACMP组左右两侧海马NAA/Cr、Cho/Cr差异均无统计学意义（P均>0.05）。同一年龄亚组DEACMP组NAA/Cr均低于对照组，Cho/Cr均高于对照组，差异有统计学意义（P均<0.05）。结论 1H-MRS可检测DEACMP患者海马区代谢产物的变化，对早期诊断及评估病情具有重要意义。 |
| 英文摘要: |
| Objective To assess the changes of hippocampus metabolites in delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) using 1H-MRS. Methods Totally 43 DEACMP patients (DEACMP group) and 30 healthy volunteers (control group) were recruited, and subjects in both groups were further divided into young (<50 years old) and aged subgroup (≥50 years old). All subjects underwent 1H-MRS scanning of bilateral hippocampus. 2D-1H-MRS point-resolved spectroscopy was performed to obtain N-acetylaspartic acid/creatine (NAA/Cr) and choline/creatine (Cho/Cr). The data was then analyzed with t-test. Results There were no significant differences between left and right hippocampus in both groups (all P>0.05). In both young and aged subgroups, NAA/Cr of DEACMP patients decreased and Cho/Cr increased compared with controls (all P<0.05). Conclusion 1H-MRS can detect metabolites changes in hippocampus of patients with DEACMP, which has important significance in early diagnosis and assessment of DEACMP. |
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