| 富丽萍,张熙,张锦明,张晓军,张增强,王盼,周波,徐白萱,田嘉禾.早期相11C-PIB作为神经功能指标：与18F-FDG比较分析[J].中国医学影像技术,2013,29(12):1918~1922 |
| 早期相11C-PIB作为神经功能指标：与18F-FDG比较分析 |
| Early phase 11C-PIB as neurofunctional index：Comparison with 18F-FDG |
| 投稿时间：2013-05-27 修订日期：2013-10-16 |
| DOI： |
| 中文关键词: 阿尔茨海默病 11C-PIB 18F 氟脱氧葡萄糖 灌注成像 正电子发射型体层摄影术 |
| 英文关键词:Alzheimer disease 11C-PIB Fluorodeoxyglucose F18 Perfusion imaging Positron-emission tomography |
| 基金项目:国家自然科学基金青年科学基金项目（30900352）、中国博士后科学基金（20090461433）。 |
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| 中文摘要: |
| 目的 评价早期相动态11C-PIB可否提供等价于18F-FDG的神经功能信息。方法 对17名正常对照（NC组）、11例轻度认知障碍（MCI）患者（MCI组）及15例阿尔茨海默病（AD）患者（AD组）行18F-FDG和11C-PIB双示踪剂检查，通过训练集（3名NC，3例MCI及3例AD）及测试集（其余受试者）数据提取标准摄取值比（SUVR），计算与18F-FDG具有最大相关的早期相11C-PIB时间窗，生成灌注11C-PIB图像（11C-pPIB）。选取最后10 min 11C-PIB数据，评价淀粉样斑块沉积情况（11C-aPIB），比较18F-FDG、11C-pPIB及11C-aPIB图像在3组受试人群的放射性分布的差异。结果 AD组14例、MCI组 11例、NC组15名纳入分析。给药后近7 min（开始时间1.33 min，持续至8 min）的早期相11C-pPIB与18F-FDG在训练集（R=0.8680±0.0339）及测试集（R=0.8737±0.0277）均存在强烈相关。11C-pPIB与18F-FDG在3组中呈现相似的放射性分布模式，但与11C-aPIB放射性分布明显不同。结论 早期相11C-pPIB可通过反映局部脑血流信息而提供与18F-FDG相似的神经功能信息。 |
| 英文摘要: |
| Objective To explore whether 11C-labeled Pittsburgh compound-B (11C-PIB) in early phase could provide neurofunctional information equivalent to 18F-FDG. Methods Seventeen normal controls (NC group), 11 mild cognitive impairment (MCI group) and 15 Alzheimer disease patients (AD group) underwent 18F-FDG and 11C-PIB PET, and 15 NC, 11 MCI and 14 AD were enrolled for analysis. 11C-pPIB images of each subject best representing perfusion were computed as a sum of 11C-PIB in early phase within a time-window which was identified on a training cohort (3 NC, 3 MCI, 3 AD) by maximizing correlation across all brain voxels between each subject's static 18F-FDG image and its pPIB image computed with different starting time points and varied frame ranges. The optimal time-window for perfusion determined on training cohort was validated on the rest 31 subjects. The sum of 10 min increment of 11C-PIB frames, referred to as 11C-aPIB, was computed to evaluate amyloid-β plaque deposits. Results An early 7-min window yielded the highest correlation between 18F-FDG and 11C-pPIB (R=0.87±0.03). 11C-pPIB images shared a similar radioactive distribution pattern with their corresponding 18F-FDG images in all groups. Conclusion The high correlation between 11C-pPIB and 18F-FDG values strongly suggested that 11C-pPIB could serve as a surrogate biomarker of rCBF for measuring neural activities. The dual-biomarker 11C-PIB analysis (11C-pPIB+11C-aPIB) may play an active role in clinical applications for amyloid-related process. |
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