| 刘芳,杨敏,刘勇,曾怡明,顾小宁,刘冬梅.探讨应用血管回声跟踪技术评价妊娠期糖尿病患者血管内皮功能及危险因素[J].中国医学影像技术,2013,29(11):1829~1832 |
| 探讨应用血管回声跟踪技术评价妊娠期糖尿病患者血管内皮功能及危险因素 |
| Evaluation of vascular endothelial function and related risk factors in gestational diabetes mellitus patients with echo-tracking technique |
| 投稿时间：2013-05-29 修订日期：2013-07-14 |
| DOI： |
| 中文关键词: 糖尿病,妊娠 内皮功能 超声检查 回声跟踪技术 |
| 英文关键词:Diabetes, gestational Endothelial function Ultrasonography Echo-tracking technique |
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| 中文摘要: |
| 目的 应用血管回声跟踪(ET)技术评价妊娠期糖尿病(GDM)患者出现血管并发症之前有无血管内皮功能损害,并分析影响血管内皮功能的相关危险因素。方法 收集GDM患者50例(GDM组)和正常孕妇50名(对照组),应用ET技术检测肱动脉,获得血管内皮功能参数,比较两组血管内皮功能参数和妊娠前体质量指数(BMI)、空腹血糖(FBG)、餐后1 h血糖(P1hPG)、餐后2 h血糖(P2hPG)、总胆固醇(TC)、甘油三酯(TG)及胰岛素抵抗指数(IR)的差异;以BMI、FBG、P1hPG、P2hPG、TC、TG、IR为自变量,以血管硬化度(β)、脉搏波传导速度(PWVβ)、弹性系数(Eρ)和顺应性(AC)为因变量,行多因素多元逐步线性回归分析,分析影响血管内皮功能的相关危险因素。结果 GDM组β、PWVβ、Eρ、 BMI、FBG、P1hPG、P2hPG、TC、TG、IR均较对照组增高,AC较对照组减低(P均<0.05);IR、FBG对β,IR对PWVβ,TG对Eρ,BMI对AC有显著危险性(P均<0.05)。结论 GDM患者在出现血管并发症之前即有发生血管内皮功能损害的可能;产前有效调整及控制孕妇体质量、FBG、TG及胰岛素水平对防治GDM患者血管内皮功能损害有重要意义。 |
| 英文摘要: |
| Objective To evaluate vascular endothelial function before vascular complications appearing in gestational diabetes mellitus (GDM) patients by using echo-tracking (ET) technique, and to observe related risk factors. Methods Fifty GDM patients (GDM group) and 50 normal pregnant women (control group) were collected, body mass index (BMI) before pregnancy, fasting blood glucose (FBG), blood glucose 1 h after meal (P1hPG) and 2 h after meal (P2hPG), total cholesterol (TC), triglyceride (TG) and insulin resistance index (IR) were compared. The brachial artery was detected with ET, the parameters of vascular endothelial function were obtained and compared between the two groups. Taking BMI, FBG, P1hPG, P2hPG as independent variables, stiffness parameter (β), pulse wave velocity (PWVβ), pressure-strain elastic modulus (Eρ), arterial compliance (AC) as dependent variables, stepwise linear regression analysis was made. Results Compared with those in control group, β, Ep, PWVβ, BMI, FBG, P1hPG, P2hPG, TC, TG and IR increased, but AC decreased in GDM group (all P<0.05). There was significant relationship between IR and β, FBG and β, IR and PWVβ, TG and Eρ, BMI and AC (all P<0.05). Conclusion Vascular endothelial dysfunction may exist before vascular complications appearing in GDM patients. Effective adjustment and control of body mass, FBG, TG and IR before pregnancy are important to prevent and cure vascular endothelial dysfunction in GDM patients. |
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