| 林建忠,杨天和,郑慈娜,康泰山,李晓清,曾强,王月琴,林玉琳,王建腾.探索高原登山的脑结构改变[J].中国医学影像技术,2013,29(10):1589~1592 |
| 探索高原登山的脑结构改变 |
| Cerebral structural alterations after high altitude mountain-climbing |
| 投稿时间：2013-05-21 修订日期：2013-06-18 |
| DOI： |
| 中文关键词: 磁共振成像 灰质 白质 萎缩 |
| 英文关键词:Magnetic resonance imaging Gray matter White matter Atrophy |
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| 中文摘要: |
| 目的 探讨一次短暂高原登山引起的脑结构改变.方法 对15名厦门大学学生登山队员[男9名,女6名,19~23岁,平均(21.0±1.1)岁]分别于攀登珠穆朗玛峰前、后进行常规T2W及高分辨率全脑3DT1W结构成像;应用SIENA软件分别对登山前、后高分辨率3DT1W结构像进行全脑灰质、白质分割,计算体积萎缩百分率,并进行统计分析;对全脑进行基于体素的纵向脑萎缩评价,获取显著萎缩脑区.结果 视觉观察,登山前、后所有登山队员常规T2WI均未发现异常,但脑灰质及白质体积均有明显减少,脑灰质萎缩百分率为(2.70±1.43)%,白质萎缩百分率为(1.43±1.36)%,差异有统计学意义(P<0.01);基于体素的全脑统计分析发现,萎缩脑区包括左侧额叶、胼胝体压部、双侧颞极、双侧枕叶距状沟周围及双侧小脑半球,以优势半球受损明显.结论 高原登山运动可引起脑白质和灰质萎缩,且灰质萎缩更明显. |
| 英文摘要: |
| Objective To investigate cerebral structural alterations after single short-term high-altitude mountain climbing. Methods Fifteen healthy mountain climbing amateurs (9 males, 6 females, aged 19-23, mean[21.0±1.1] years) from Xiamen University who successfully completed mountain climbing underwent whole brain image scanning before and after the activity, respectively, and high resolution T1WI and routine T2WI were obtained using 1.5T MR system. The images were analyzed using SIENA to normalize the head size and segment brain tissue for each subject. The total volume of brain tissue (including separate estimates of volumes of grey matter and white matter) was analyzed statistically. Longitudinal evaluation on cerebral atrophy voxel for all subjects were performed to identify the significant atrophy brain regions. Results No high signal intensity on T2WI was observed, but there was significant loss of both gray matter and white matter volume. The atrophy percentage of gray matter and white matter was (2.70±1.43)% and (1.43±1.36)% (P<0.01), respectively. Significant atrophy brain regions were observed with voxel wise multi-subject SIENA statistics including left frontal lobe, splenium of corpus callosum, bilateral temporal poles, bilateral occipital lobes peripheral and cerebellum. Brain regions in dominant hemisphere were damaged significantly. Conclusion High-altitude mountain climbing can cause atrophy of brain gray and white matter, and the atrophy percentage of gray matter is greater than that of white matter. |
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