| 陈佳,周京国,顾鹏,李敏,唐雪梅,梁素华.超声评价家族及散发痛风肾脏损害特征[J].中国医学影像技术,2013,29(7):1160~1164 |
| 超声评价家族及散发痛风肾脏损害特征 |
| Ultrasonic evaluation on characteristics of kidney impairment in familial and sporadic gout |
| 投稿时间：2012-11-08 修订日期：2013-06-12 |
| DOI： |
| 中文关键词: 超声检查 痛风 家族性 散发性 肾脏 |
| 英文关键词:Ultrasonography Gout Familial Sporadic Kidney |
| 基金项目:四川省科技攻关项目(2009JY0166)。 |
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| 中文摘要: |
| 目的 探讨家族及散发痛风患者肾脏声像图表现及肾脏损害特征。方法 以一个原发痛风家系成员(13例)中的4例痛风患者(家族组)及22例散发痛风患者(散发组)作为研究对象,采集血液标本进行常规及生化检查,并用彩色多普勒超声观察双肾形态、大小、回声及血流。结果 家族组的血肌酐(Cr)、尿素(Urea)及早期肾损害指标血清胱抑素C(CysC)、血清β2微球蛋白(β2-MG)值高于散发组(P<0.05)。肾脏超声显示3例出现慢性肾衰竭,包括家族组2例和散发组1例,声像图表现为双肾不同程度缩小及彩色血流信号减少;其余患者肾脏未见明显改变。家族组4例中,检出肾囊肿4例、结石2例、肾窦部及髓质回声增强及慢性肾衰竭各2例;散发组22例中,上述异常分别检出9、13、8及1例。结论 超声可作为评价痛风患者肾脏损害的重要影像学检查方法;家族性痛风肾脏损害可能较散发痛风早而严重。 |
| 英文摘要: |
| Objective To explore the clinical and ultrasonic features of kidney impairment with familial and sporadic gouty subjects. Methods Four of 13 familial gouty patients diagnosed as gout (familial group) and 22 consecutive sporadic gouty patients (sporadic group) were enrolled and underwent ultrasonography (US). The renal shape, size, echo and blood flow were observed, and the blood was tested. Results The values of serum creatinine, urea, cystatin C and blood β2-microglobulin (β2-MG) in familial group were remarkably higher than those in sporadic group. The renal shape, size and blood flow had no significant changes, excluding 3 gouty subjects (2 from familial group and 1 from sporadic group) with chronic renal failure, which were smaller in size and minor in flow. Besides, the example of renal cyst, stone, hyperechoic renal sinus and medulla and chronic renal failure in familial group was 4, 2, 2 and 2, respectively, whereas in sporadic one was 9, 13, 8 and 1, respectively. Conclusion US can be used as an important tool for evaluating kidney lesion in gout. Kidney impairment in familial patients is probably earlier and severer than that in sporadic ones. |
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