| 陈姝蓓,高大中,容顺康,黄晶,钱俊,尹富禹.高强度聚焦超声体外消融犬肾交感神经[J].中国医学影像技术,2013,29(6):867~870 |
| 高强度聚焦超声体外消融犬肾交感神经 |
| Ablation canine renal sympathetic nerve with high intensity focused ultrasound |
| 投稿时间：2013-01-06 修订日期：2013-03-31 |
| DOI： |
| 中文关键词: 高强度聚焦超声消融术 动物实验 肾交感神经 |
| 英文关键词:High-intensity focused ultrasound ablation Animal experimentation Renal sympathetic nerve |
| 基金项目:国家自然科学基金科学仪器基础专项(30527001)。 |
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| 中文摘要: |
| 目的 观察不同声功率的HIFU体外消融犬肾交感神经的损伤情况。 方法 将12只健康杂交犬随机平均分为4组,分别为消融声功率150 W组、200 W组、250 W组及对照组,以两侧肾动脉为治疗靶区进行连续直线扫描,线长10 mm,扫描线的中点与肾动脉重叠,扫描速度6 mm/s,重复消融2次。6天后将实验犬处死,对消融后的肾动脉及周围组织进行HE染色及免疫组化染色,观察肾交感神经及肾动脉的变化。 结果 经不同声功率HIFU消融后,各消融组神经均出现不同程度损伤,而肾动脉血管结构完整,与对照组相比无差异。 结论 HIFU能安全且有效地消融犬肾交感神经;声功率越高,肾交感神经损伤越明显。 |
| 英文摘要: |
| Objective To investigate the changes of canine renal sympathetic nerve after HIFU ablation with different sound power. Methods Twelve healthy hybridization canines were randomly divided into 4 groups according to sound power: 150 W group, 200 W group, 250 W group and control group (each n=3). The target area for ablation was bilateral renal artery, which underwent continuous linear scanning. The line length was 10 mm, scanning the midpoint and renal artery overlap with speed of 6 mm/s, and ablation was repeated 2 times. Six days later, all dogs were sacrificed, the ablated renal artery and surrounding tissues were harvested for HE staining and immunohistochemical examination, and the changes of renal sympathetic nerve and renal artery were observed. Results After different sound power HIFU ablation, renal sympathetic nerve showed varying degrees of injury in each ablation group, but renal artery vascular structure were still integrity, without obvious anomaly compared with control group. Conclusion HIFU is a safe and effective ablation method of canine renal sympathetic nerve. Higher sound power brought more obvious renal sympathetic nerve damage. |
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