| 邱日想,陈智毅,刘金炳,严鹏科,陈洋娣.分子影像技术应用于药物研发的研究进展[J].中国医学影像技术,2013,29(4):663~666 |
| 分子影像技术应用于药物研发的研究进展 |
| Progress of molecular imaging in drug discovery |
| 投稿时间：2012-10-19 修订日期：2013-01-25 |
| DOI： |
| 中文关键词: 分子成像 药物评价,临床前 |
| 英文关键词:Molecular imaging Drug evaluation, preclinical |
| 基金项目:广东省科技厅项目(2012B050300026);广东省自然科学基金(S2012040006593)。 |
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| 中文摘要: |
| 分子影像学具有无创、高特异性、高敏感度、高分辨率、快速实时成像等优点,用于药物研发有利于缩短研发周期、降低研发成本、提高经济效益。本文就分子影像技术在药物研发过程中的靶向表达与靶点确定、药物先导化合物筛选、药物动力学/微剂量评价、抗肿瘤药物的有效性评估、纳米技术药物的缓释与成像等方面进行综述。 |
| 英文摘要: |
| Molecular imaging is noninvasive, having high specificity, high sensitivity, high resolution and rapid real-time imaging, therefore playing an important role in drug development. It can not only shorten the development cycle, but also reduce the research cost and improve the economic benefit. The application of molecular imaging in assessment of the target expression and target determination, screening of drug lead compound, assessment of drug dynamics/micro dose, evaluation of antitumor drug's effectiveness, delivery and imaging of nanotechnological drug in drug development were reviewed in this article. |
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