| 薛蕴菁,高培毅,林燕,段青.基于血管影像的人体颈动脉分叉血流模式分型[J].中国医学影像技术,2013,29(3):476~479 |
| 基于血管影像的人体颈动脉分叉血流模式分型 |
| Type of flow patterns of human carotid bifurcation based on computational fluid dynamics and MR angiography |
| 投稿时间：2012-09-18 修订日期：2012-12-20 |
| DOI： |
| 中文关键词: 计算机模拟 颈动脉 血流动力学 磁共振成像 |
| 英文关键词:Computational simulation Carotid arteries Hemodynamics Magnetic resonance imaging |
| 基金项目: |
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| 摘要点击次数: 3519 |
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| 中文摘要: |
| 目的: 应用计算流体力学(CFD)方法结合血管影像分析在体颈动脉分叉的血流模式分型。方法: 收集50例接受增强MRA(CEMRA)的患者,共100支颈动脉血管,经颈动脉超声或DSA证实双侧颈动脉分叉管腔正常。CEMRA原始图像经计算机三维重建及网格化后,采用CFD方法进行计算,于颈动脉分叉平面观察分析在心动周期减慢射血期时的血流模式;同时应用vmtk软件测量颈动脉分叉的分叉角。结果: 根据颈动脉分叉处的涡流形态,可将血流模式分为4型,即无涡流型 (8支)、单涡流型(25支)、双涡流型(61支)和多涡流型(6支)。根据分叉角的大小及球部的大小,100支颈动脉分叉形态可分为4型,即小角度小球型(14支)、小角度大球型(5支)、大角度小球型(49支)和大角度大球型(32支)。结合颈动脉分叉血管几何形态和分叉平面的涡流形态,发现颈动脉球部越大、分叉角越大,则涡流形态越复杂,且为大涡流。结论: 应用CFD方法结合血管影像分析正常颈动脉分叉血液的血流模式分型,有助于进一步理解颈动脉几何形态与复杂血流模式的相关性。 |
| 英文摘要: |
| Objective: To investigate flow patterns at carotid bifurcation in vivo with combining computational fluid dynamics (CFD) and MRA. Methods: Fifty patients with 100 normal carotid bifurcations proved with DSA or carotid ultrasound underwent contrast-enhanced MRA (CEMRA) of carotid artery. The source images were imported into CFD software to calculate and visualize flow pattern after post-processing and meshed. Flow patterns and eddy shape of bifurcation plane in reduced ejection phase of a cardiac cycle were analyzed. The carotid bifurcation angles were measured with vmtk software. Results: According to the shape of eddy current, the flow patterns could be classified as non-eddy type (n=8), one eddy type (n=25), two-eddy type (n=61) and multiple-eddy type (n=6). There were four types in bifurcation geometry based on the bifurcation angle and diameter of bifurcation, i.e. small bulb with small bifurcation angle (n=14), small bulb with big bifurcation angle (n=5), big bulb with small bifurcation angle (n=49) and big bulb with big bifurcation angle (n=32). The more big bifurcation angle and bulb, the more complicated flow pattern was observed at carotid bifurcation. Conclusion: CFD combined with MR angiography can be utilized to visualize and analyze flow patterns and the shape of eddy current of carotid bifurcation, therefore being helpful to understanding the relationship between hemodynamic factors and artherosclerosis. |
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