| 陈少伯,赵季红,梁国庆,姜铁民,李玉明.血管内超声-虚拟组织成像在冠状动脉临界病变中的应用[J].中国医学影像技术,2013,29(3):380~384 |
| 血管内超声-虚拟组织成像在冠状动脉临界病变中的应用 |
| Application of intravascular ultrasound visual histology in patients with intermediate coronary artery stenosis |
| 投稿时间：2012-08-25 修订日期：2013-01-05 |
| DOI： |
| 中文关键词: 腔内超声检查 虚拟组织学 冠状动脉狭窄 血流储备分数 |
| 英文关键词:Endosonography Visual histology Coronary stenosis Fractional flow reserve |
| 基金项目: |
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| 摘要点击次数: 2591 |
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| 中文摘要: |
| 目的: 探讨血管内超声-虚拟组织成像(IVUS-VH)在冠状动脉临界病变中的应用价值。方法: 收集CAG检查显示冠状动脉狭窄率40%～70%的96例患者,先后进行IVUS-VH和冠状动脉血流储备分数(FFR)检查;以FFR<0.75者作为FFR异常组(n=29),FFR≥0.75者作为FFR正常组(n=67),分析两组IVUS-VH参数和FFR的相关性。结果: FFR正常组与FFR异常组病变最小管腔面积分别为(4.26±1.87)mm2及(3.45±1.31)mm2,差异有统计学意义(P<0.05),坏死组织面积/钙化性斑块面积(NC/DC)分别为2.23±1.82与3.54±2.07,差异有统计学意义(P<0.01);最小管腔面积与FFR呈正相关(r=0.47,P<0.05),NC/DC与FFR呈负相关(r=-0.63,P<0.05),以最小管腔面积<4.0 mm2结合NC/DC>3.0作为截点,预测FFR<0.75的敏感度为88%,特异度为85%。结论: 应用IVUS-VH、以冠状动脉最小管腔面积<4.0 mm2结合NC/DC>3.0为标准指导冠状动脉临界病变介入治疗更为合理。 |
| 英文摘要: |
| Objective: To explore the value of intravenous ultrasound-visual histology (IVUS-VH) in patients with intermediate coronary artery stenosis. Methods: Ninety-six patients with intermediate stenosis coronary arteries (stenosis rate 40%-70% by CAG) were collected and underwent fractional flow reserve (FFR) and IVUS. Then according to the results of FFR, the patients were divided into FFR normal group (FFR≥0.75, n=67) and FFR abnormal group (FFR<0.75, n=29). The correlation between parameters of IVUS-VH and FFR was analyzed. Results: The minimal lumen cross-sectional area (MLA) was (4.26±1.87)mm2 in FFR normal group and (3.45±1.31)mm2 in FFR abnormal group(P<0.05), necrotic area/dense calcium area (NC/DC) was (2.23±1.82) in FFR normal group and (3.54±2.07) in FFR abnormal group, respectively (P<0.01). MLA had positive correlation with FFR (r=0.47, P<0.05), and NC/DC had negative correlation with FFR (r=-0.63, P<0.05). Taking MLA<4.0 mm2 combined with NC/DC>3.0 as the best cut-off value to forecast FFR<0.75, the sensitivity was 88%, and the specificity was 85%. Conclusion: MLA<4.0 mm2 combined with NC/DC>3.0 is a more reasonable criteria for intervention for patients with intermediate coronary artery stenosis. |
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