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饶良俊,王晓燕,陈志丰,罗炳棋,张祥松,史新冲,易畅.对比分析^99mTc-MDP SPECT与¹⁸F-NaF PET/CT术前诊断肺癌骨转移的价值[J].中国医学影像技术,2012,28(12):2233~2238

对比分析^99mTc-MDP SPECT与¹⁸F-NaF PET/CT术前诊断肺癌骨转移的价值

Comparison of preoperative ^99mTc-MDP SPECT and ¹⁸F-NaF PET/CT
in diagnosis of bone metastases in patients with lung cancer

投稿时间：2012-03-03 修订日期：2012-04-04

DOI：

中文关键词: 肺肿瘤肿瘤转移体层摄影术,X线计算机体层摄影术,发射型计算机,单光子正电子发射型体层摄影术 ^99m 锝亚甲基二磷酸 ¹⁸F-氟化钠

英文关键词:Lung neoplasms Neoplasm metastasis Tomography, X-ray computed Tomography, emission-computed, single-photon Positron-emission tomography Technetium Tc 99m medronate ¹⁸F-NaF

基金项目:

作者	单位	E-mail
饶良俊	中山大学附属第一医院核医学科, 广东广州 510080
王晓燕	中山大学附属第一医院核医学科, 广东广州 510080
陈志丰	中山大学附属第一医院核医学科, 广东广州 510080
罗炳棋	中山大学附属第一医院核医学科, 广东广州 510080
张祥松	中山大学附属第一医院核医学科, 广东广州 510080	sd-zh@163.net
史新冲	中山大学附属第一医院核医学科, 广东广州 510080
易畅	中山大学附属第一医院核医学科, 广东广州 510080

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中文摘要:

目的对比分析^99mTc-亚甲基二膦酸盐(MDP)SPECT与¹⁸F-氟化钠(NaF)PET/CT术前诊断肺癌骨转移灶的临床价值。方法回顾性分析274例肺癌患者,其中107例接受¹⁸F-NaF PET/CT检查,167例接受^99mTc-MDP SPECT检查,以病理学结果或随访结果作为标准进行分析。结果 107例肺癌术前¹⁸F-NaF PET/CT显像中,2例骨骼病灶性质待定;167例^99mTc-MDP SPECT显像中, 18例骨骼病灶性质待定。¹⁸F-NaF PET/CT和^99mTc-MDP SPECT术前诊断肺癌骨转移灶的灵敏度分别为100%(32/32)和87.72%(50/57),前者高于后者(P=0.046),特异度分别为98.67%(74/75)和92.73%(102/110),差异无统计学意义(χ²=2.237,P=0.135);二者的准确率分别为99.07%(106/107)和91.02%(152/167),前者高于后者(χ²=6.287,P=0.012)。结论 ¹⁸F-NaF PET/CT骨显像术前评价肺癌骨转移较^99mTc-MDP SPECT的灵敏度和准确率高,是肺癌术前评价骨转移的较好方法。

英文摘要:

Objective To compare the value of preoperative ^99mTc-methylene diphosphona (MDP) SPECT and ¹⁸F-sodium fluride (NaF) PET/CT in diagnosis of bone metastases in patients with lung cancer. Methods Data of 274 lung cancer patients were analyzed retrospectively, including 107 patients underwent ¹⁸F-NaF PET/CT imaging and 167 underwent ^99mTc-MDP SPECT imaging. Taking the results of pathology or follow-up as standards, ¹⁸F-NaF PET/CT and ^99mTc-MDP SPECT were compared. Results There were only 2 equivocal patients with ¹⁸F-NaF PET/CT imaging among 107 patients, while 18 with ^99mTc-MDP SPECT imaging in 167 patients. The sensitivity of ¹⁸F-NaF PET/CT and ^99mTc-MDP SPECT was 100% (32/32) and 87.72% (50/57), respectively, the former was higher than the latter (P=0.046), and the specificity was 98.67% (74/75) and 92.73% (102/110), respectively (χ²=2.237, P=0.135). The accuracy rate of ¹⁸F-NaF PET/CT and ^99mTc-MDP SPECT was 99.07% (106/107) and 91.02% (152/167), respectively (χ²=6.287, P=0.012). Conclusion The sensitivity and accuracy rate of preoperative ¹⁸F-NaF PET/CT in evaluation bone metastases in patients with lung cancer are higher thanthose of ^99mTc-MDP SPECT, suggesting that ¹⁸F-NaF PET/CT is a good method for diagnosing bone metastases in patients with lung cancer.

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