| 申景涛,辛小燕,贾支俊,朱斌,郭万华.结直肠癌18F-FDG的摄取与Glut-1表达的相关性[J].中国医学影像技术,2012,28(12):2185~2188 |
| 结直肠癌18F-FDG的摄取与Glut-1表达的相关性 |
| Relationship between 18F-fluorodeoxyglucose uptake and expression of Glut-1 in colorectal cancer |
| 投稿时间：2012-05-07 修订日期：2012-08-06 |
| DOI： |
| 中文关键词: 结直肠肿瘤 正电子发射型体层摄影术 体层摄影术,X线计算机 18F 氟脱氧葡萄糖 葡萄糖转运蛋白-1 |
| 英文关键词:Colorectal neoplasms Positron-emission tomography Tomography, X-ray computed Fluorodeoxyglucose F18 Glucose transporter-1 |
| 基金项目:国家自然科学基金(81171363);江苏省卫生厅"十二五科教兴卫"医学重点人才项目(RC2011014)。 |
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| 中文摘要: |
| 目的 探讨结直肠癌18F-FDG摄取与肿瘤组织葡萄糖转运蛋白-1(Glut-1)表达的相关性。 方法 对20 例结直肠癌患者术前进行18F-FDG PET/CT检查,测定肿瘤平均标准摄取值(SUVmean);对手术切除标本进行病理检查,并应用免疫组织化学法检测肿瘤组织Glut-1的表达。分析SUVmean值与组织病理关系及与Glut-1表达的相关性。 结果 20例结直肠癌均为高摄取,SUVmean值为5.42±1.67。大体分型中,浸润型结直肠癌的SUVmean值(6.55±1.63)高于肿块型(4.20±1.29)和溃疡型(5.83±1.60),但差异无统计学意义(P>0.05)。M分期中,远处转移者的SUVmean值(7.14±1.07)高于无转移者(4.84±1.41,P=0.04)。SUVmean值与Glut-1的表达呈正相关(r=0.53,P=0.02)。 结论 结直肠癌18F-FDG摄取(SUVmean值)与Glut-1表达呈现正相关。 |
| 英文摘要: |
| Objective To explore the relationship between 18F-fluorodeoxyglucose (18F-FDG) uptake on PET/CT and the expression of glucose transporter-1(Glut-1) in patients with colorectal cancer. Methods Twenty patients with colorectal cancer were imaged with 18F-FDG PET/CT before operation. The mean standard uptake value (SUVmean) was measured. Resected tumor samples were pathologic examined. The expression of Glut-1 was graded semiquantitatively by immunohistochemistry. The correlation of histopathology, Glut-1 and SUVmean were analyzed. Results 18F-FDG uptakes of colorectal cancer were high, and the SUVmean was 5.42±1.67. According to the morphous classification, SUVmean of infiltrating type colorectal cancer (6.55±1.63) was higher than that of mass type (4.20±1.29) and ulcer type (5.83±1.60), but there was no significantly different (P>0.05). SUVmean of colorectal cancer with metastasis (7.14±1.07) was higher than that of non-metastasis (4.84±1.41) (P=0.04). There was significant positive correlation between SUVmean and expression of Glut-1 (r=0.53, P=0.02). Conclusion Expression of Glut-1 correlates with 18F-FDG uptake (SUVmean) in patients with colorectal cancer. |
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